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2. Reduced ghrelin in endothelial cells plays important mechanistic role in aging-related impairment of angiogenesis.

Author

Ahluwalia, A, Li, A, Cheng, G, Deng, X, and Tarnawski, A S

Subjects
Aged, Aged, 80 and over, Aging: physiology, Capillaries: drug effects, physiology, Cell Line, Cell Movement: drug effects, Cell Proliferation: drug effects, Dose-Response Relationship, Drug, Endothelial Cells: cytology, drug effects, metabolism, Endothelium, Vascular: cytology, metabolism, Extracellular Signal-Regulated MAP Kinases: metabolism, Ghrelin: metabolism, pharmacology, Humans, Infant, Newborn, MAP Kinase Signaling System: drug effects, physiology, Neovascularization, Physiologic: drug effects, Phosphorylation, Receptors, Ghrelin: metabolism, ghrelin, human microvascular endothelial cells, aging, angiogenesisischemia-reperfusion injury, growth-hormone secretagogue, induced gastroprotection, acylated peptide, heart-failure, expression, rats, age, activation, receptor, Aged, Aged, 80 and over, Aging: physiology, Capillaries: drug effects, physiology, Cell Line, Cell Movement: drug effects, Cell Proliferation: drug effects, Dose-Response Relationship, Drug, Endothelial Cells: cytology, drug effects, metabolism, Endothelium, Vascular: cytology, metabolism, Extracellular Signal-Regulated MAP Kinases: metabolism, Ghrelin: metabolism, pharmacology, Humans, Infant, Newborn, MAP Kinase Signaling System: drug effects, physiology, Neovascularization, Physiologic: drug effects, Phosphorylation, Receptors, Ghrelin: metabolism, ghrelin, human microvascular endothelial cells, aging, angiogenesisischemia-reperfusion injury, growth-hormone secretagogue, induced gastroprotection, acylated peptide, heart-failure, expression, rats, age, activation, receptor
Abstract

Ghrelin, a hormone produced mainly by gastric mucosal cells stimulates growth hormone (GH) release. Ghrelin is also expressed in the endothelial cells of blood vessels suggesting its physiological role and a function in these cells. We recently demonstrated that ghrelin induces angiogenesis--new capillary blood vessel formation- in neonatal human microvascular endothelial cells (HMVECs). Angiogenesis is impaired in aging individuals both in vitro and in vivo, but the precise mechanism(s) of this phenomenon is unknown. We examined whether HMVECs derived from aging individuals (66 years and 90 years old), 66-HMVECs and 90-HMVECs have reduced ghrelin levels vs. neonatal (Neo) HMVECs and whether treatment with exogenous ghrelin can restore impaired in vitro angiogenesis on matrigel in aged HMVECs. Ghrelin levels were reduced in the aged HMVECs by 3.2-fold (p

Published
2009

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