1. Urine Biomarkers and Perioperative Acute Kidney Injury: The Impact of Preoperative Estimated GFR
- Author
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Koyner, Jay L, Coca, Steven G, Thiessen-Philbrook, Heather, Patel, Uptal D, Shlipak, Michael G, Garg, Amit X, Parikh, Chirag R, Consortium, Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury, Raman, Jai, Jeevanandam, Valluvan, Akhter, Shahab, Devarajan, Prasad, Bennett, Michael, Ma, Qing, Griffiths, Rachel, Edelstein, Charles, Passik, Cary, Nagy, Judy, Swaminathan, Madhav, Chu, Michael, Goldbach, Martin, Guo, Lin Ruo, McKenzie, Neil, Myers, Mary Lee, Novick, Richard, Quantz, Mac, Schumann, Virginia, Webster, Laura, Zappitelli, Michael, Palijan, Ana, Dewar, Michael, Darr, Umer, Hashim, Sabet, Elefteriades, John, Geirsson, Arnar, Garwood, Susan, Kemp, Rowena, and Butrymowicz, Isabel
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Kidney Disease ,Clinical Research ,Renal and urogenital ,Acute Kidney Injury ,Aged ,Aged ,80 and over ,Biomarkers ,Cardiac Surgical Procedures ,Cohort Studies ,Creatinine ,Cystatin C ,Female ,Glomerular Filtration Rate ,Humans ,Male ,Middle Aged ,Postoperative Complications ,Prospective Studies ,Urine biomarkers ,interleukin 18 ,liver-type fatty acid binding protein ,acute renal failure ,acute kidney injury ,perioperative AKI ,effect modification ,estimated glomerular filtration rate ,prognosis ,cardiac surgery ,surgical complication ,Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury (TRIBE-AKI) Consortium ,Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury TRIBE-AKI Consortium ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundThe interaction between baseline kidney function and the performance of biomarkers of acute kidney injury (AKI) on the development of AKI is unclear.Study designPost hoc analysis of prospective cohort study.Setting & participantsThe 1,219 TRIBE-AKI Consortium adult cardiac surgery cohort participants.PredictorUnadjusted postoperative urinary biomarkers of AKI measured within 6 hours of surgery.OutcomeAKI was defined as AKI Network stage 1 (any AKI) or higher, as well as a doubling of serum creatinine level from the preoperative value or the need for post-operative dialysis (severe AKI).MeasurementsStratified analyses by preoperative estimated glomerular filtration rate (eGFR) ≤ 60 versus > 60mL/min/1.73m(2).Results180 (42%) patients with preoperative eGFRs≤60mL/min/1.73m(2) developed clinical AKI compared with 246 (31%) of those with eGFRs>60mL/min/1.73m(2) (P
- Published
- 2015