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The study included 41 patients aged 50.0 (39.0, 55.0) years, of which 29 men (70.7%) and 12 women (29.3%) with diabetes type 2 and metabolic syndrome in terms of voluntary informed consent. We studied the effect of combined treatment (correction of physical activity, the formation of healthy food, metformin) for the maintenance of premature aging markers p53 protein in these patients. Apoptosis was studied by determining serum - p53 (U/ml) by ELISA. In patients with type 2 diabetes and metabolic syndrome increased apoptosis - the content of p53 in the serum reaches 1,9 (1,79; 2,3) U/ml. Against the background of complex treatment of the protein content decreased to 0,98 (0,93; 1,1) U/ml.

The aim of this investigation was to improve the effectiveness of the complex treatment of chronic destructive periodontitis. Complex treatment included endodontical, antibacterial, antihistaminic and sorptive therapy. The data obtained were evaluated in terms of 14 days and after the year, compared with the control group. The results of the study demonstrated the effectiveness of the purpose of chronic destructive periodontitis treatment.

The article presents data about the efficiency of glossalgia and stomatalgia complex treatment. This pathology is rather widespread and distresses patients. The diseases are polygenic, pathogenesis is unplumbed, and treatment methods are multivarious and not always effective. This fact determined the timeliness of the chosen issue. For many years we have been applying different treatment methods. The received results allowed us to recommend some of them, for example cranial electrotherapy stimulation, cryotherapy, hirudotherapy, laser treatment, local immunomodulators, rinsing with antiseptics, split meals, examination by interns if indicated, and general treatment prescribed by different doctors.