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This review is about nonsteroidal anti-inflammatory drugs and different approaches to development of pharmaceutical forms for controlled nonsteroidal anti-inflammatory drug release. Natural and synthetic biocompatible polymers used as drug carriers were considered. Different methods used for production of polymeric microparticles and formulations of nonsteroidal anti-inflammatory agents based on them were discussed. Characterization of microparticles with encapsulated nonsteroidal anti-inflammatory agents was given.

The study is devoted to novel manufacturing method of preparation of polymeric microparticles, loaded by naltrexone base, in flow through regime. Special module construction was developed for providing emulsification in continuous regime. Focusing on production of polymeric microparticles with characteristics, compatible with characteristics of the pharmaceutical Vivitrol and its native analogue, parameters of encapsulation process were defined. An ability of prepared microparticles to prolonged drug release during 28 days was demonstrated.