1. Improving blood pressure control, organoprotection and metabolic disorders correction in patients with hypertension switching from diuretic-based combinations to fixed combination lisinopril + amlodipine + rosuvastatin
- Author
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S. V. Nedogoda, A A Ledyaeva, V Yu Khripaeva, E. V. Chumachek, E. A. Popova, V. O. Smirnova, A. S. Salasyuk, V. V. Tsoma, and R V Palashkin
- Subjects
medicine.medical_specialty ,arterial hypertension ,lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_treatment ,pulse wave velocity ,central blood pressure ,amlodipine ,augmentation index ,leptin ,Hydrochlorothiazide ,Internal medicine ,Medicine ,Rosuvastatin ,Amlodipine ,Pulse wave velocity ,business.industry ,indapamide ,Indapamide ,lisinopril ,Lisinopril ,hydrochlorothiazide ,Blood pressure ,inflammation ,lcsh:RC666-701 ,Cardiology ,Diuretic ,business ,rosuvastatin ,medicine.drug ,circulatory and respiratory physiology - Abstract
The aim of the study was to assess the possibility of fixed combination Lisinopril + amlodipine + rozuvastatin to improve arterial elesticity in patients with hypertension and high pulse wave velocity, despite previous diuretic-based combination antihypertensive therapy. Materials and methods. In an open, observational study duration of 24 weeks was included 60 patients on previous diuretic-based combination antihypertensive therapy. All participants underwent 24-hour blood pressure monitoring, applanation tonometry (augmentation index and central blood pressure), pulse wave velocity measurement, laboratory tests (lipid profile, fasting glucose, insulin resistance index - NOMA), leptin, high-sensitivity C-reactive protein before and after the switching to a fixed combination of lisinopril + amlodipine + rosuvastatin. Results. According to measurements of office blood pressure switching of patients on double combinations based on diuretics to a fixed combination of lisinopril + amlodipine + rosuvastatin, a further decrease in systolic blood pressure (SBP) by 13.7% and diastolic BP (DBP) by 18.8% was observed. According to the ABPM, the decline in the average daily SBP was 15.8%, DBP - 22.5%, average SBP - 16.2%, DBP - 19.8%. The combination of lisinopril + amlodipine + rosuvastatin reduced PWV by 15.9%, augmentation index by 13.5%, central SBP by 8.4% (p
- Published
- 2018