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Background and Objective: Epidemiological study in Oral lesions and diseases can help to identify risk factors for preventing diseases. Therefore, the present study aimed to determine the frequency of salivary gland lesions in a pathology laboratory of Hamedan dental school and Besat Hospital. Materials and Methods: In this descriptive cross-sectional study all records of patients from 2006 to 2017 were reviewed by referring to the Department of Pathology of Hamadan Dental School and Archives of Besat Hospital. The required data including histopathologic diagnosis and anatomic location of lesions, age and gender were recorded and the data were analyzed using SPSS v.16 statistical software. Results: The results showed that salivary lesions comprise 6/63% of total head and neck lesions, of which 65.4%, 24.3% and 10.3% of lesions were non-neoplastic and benign and malignant neoplastic lesions respectively. Also, the forecasting of the incidence of cases for the next three years was at least 6.20% and a maximum of 10.36%. Conclusion: The results of this study suggested that future studies with more emphasis on clinicians will provide more accurate information about patients. Also, extensive studies are suggested in other cities and provinces with a longer period of time.