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Objective: We aimed to determine the levels of sUA and sUA /creatinine ratios in stable COPD patients and to evaluate whether they can be used as a predictor of exacerbation risk and the disease severity. Methods: The levels of sUA and sUA/creatinine ratio evaluated and their correlations with the parameters studied were investigated.ROC analyses of sUA and sUA/creatinine ratio for exacerbation risk and the diseases severity were done. Results: The mean sUA levels and sUA/creatinine ratio were significantly higher in the patient group (n=110) compared to healthy controls (n=52).In the cases with comorbidity, sUA levels were significantly high.While there was no association between sUA levels and all the parameters studied, a positive correlation was detected between sUA/creatinine ratio and smoking pack/years (r=0.21, p=0.038), body mass index (r=0.35, p=0.004) and with CAT scores (r=0.31, p=0.007), and a negative correlation was detected with FVC (r= -0.25, p=0.017).The ROC analyses indicated that sUA/creatinine ratio was more specific than sUA levels alone with a similar sensitivity in increased values and more sensitive with similar specificity in the lower values for both exacerbation and severity of disease. Conclusion: Serum UA levels and sUA/creatinine ratio were higher in patients with COPD compared to healthy controls.Their levels increase in the presence of certain comorbidities. However, serum UA/creatinine ratio appears to be more useful in predicting risky patients for exacerbation and disease severity with high sensitivity but low specificity.