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This paper presents the design and simulation of the 64 channel analogue multiplexer for neural signal recording system designed in CMOS 180 nm technology. Single channel sampling rate is 100 kHz and linear range of the input signal is +/-400 mV. For noise cancellation caused by digital part of the differential architecture with dummy channel has been used.

We present the design and simulation of the neural recording amplifier in the CMOS 180 nm technology. Amplifier is capable of recording signals from mHz range up to kHz range while rejecting large DC offset generated on the electrode-electrolyte interface. Its band may be control to span over all interesting biopotential signals (low cutoff frequency from 73 mHz to 125 Hz while the upper cutoff frequency from 1.85 kHz to 16.5 kHz). Due to its low input referred noise 4.5 muV (integrated from 1 mHz to 100 kHz), low power consumption 28 muW per one channel, small occupied area 0.094 mm2 and small spreads of its main parameters designed amplifier is a good candidate for multichannel neural recording system.