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Three-dimension geological simulation engine is the key to geological environment simulation which can visually support geological resource exploration and analysis. Design of a three-dimension geological simulation engine is presented in this paper firstly. The engine is then fully implemented and applied in a case study in the southern margin of Yili basin to verify its feasibility. In the case study, the proposed three-dimension geological simulation engine is proven able to efficiently support specific research on sandstone-type uranium deposits, in which the surface and underground geological environment simulated, the interlayer oxidation zone front ascertained, and the information of strata and metallogenic favorability extracted. [ABSTRACT FROM PUBLISHER]