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In this paper, we have newly designed and fabricated horseshoe-shaped skin attachable minimally invasive wearable patch with implantable microneedle biosensor for continuous glucose monitoring in interstitial fluid (ISF). In order to reduce the effects of skin movement or external stress on the fabricated sensor, we considered both hardness and stretchability of the microneedle and appropriate material. The fabricated microneedle biosensor exhibited an excellent amperometric response to glucose molecules as much as $128.65\ \mu \mathrm{A}/\text{mM}\cdot \text{cm}^{2}$ and ultra-low limit of detection (LOD) as $0.198\ \mu \mathrm{M}$ . Furthermore, the linear range of the sensor was indicated up to 30 mM in two glucose concentration regions.

In this research, we have newly developed a highperformance conductive hydrogel hybrid sensor based on polyacrylamide (PAAm) and poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) for simultaneous detection of pressure and temperature which applies to artificial neural and skin system. The proposed sensor can detect the pressure through the variation of electrical double layer (EDL) capacitance between two electrodes and hydrogel containing PEDOT:PSS as well as the relative temperature difference between the top and bottom electrodes by measuring the voltage caused by Seebeck effect simultaneously. Especially, the measured sensitivity of the temperatures variation was as much as $603\ \mu \mathrm{V}/\mathrm{K}$ in varying temperature of 0 to 30 K, and it was observed that the ammonium persulfate ions in the hydrogel contributed to the enhancement of Seebeck coefficient. The sensitivity of the pressure was indicated to 0.52 kPa−1 and 0.07 kPa−1 in the low range from 0 to 9.7 kPa and the high range from 15.2 kPa to 97 kPa, respectively.