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Start Over Topic atopic dermatitis Journal a.m.a. archives of dermatology and syphilology
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1. Occurrence of gynecomastia in conjunction with dermatologic disorders

Author

Henry T. Gray, Arthur C. Curtis, Edward P. Cawley, and Clayton E. Wheeler

Subjects
Hepatitis, Male, medicine.medical_specialty, Pathology, Cirrhosis, business.industry, Dermatology, General Medicine, Atopic dermatitis, medicine.disease, Ulcerative colitis, Skin Diseases, Gynecomastia, Metabolic Diseases, medicine, Etiology, Stilbestrol, Humans, Methyltestosterone, skin and connective tissue diseases, business, medicine.drug
Abstract

GYNECOMASTIA is known to occur in conjunction with a variety of diseases, including testicular tumor, hepatic cirrhosis and hepatitis, bronchogenic carcinoma, lung abscess, carcinoma of the adrenal cortex, transverse myelitis, hyperthyroidism, and chronic ulcerative colitis. 1 In addition, gynecomastia is a common manifestation of puberty and starvation, and it can be produced by the administration of certain hormones, including estradiol, diethylstilbestrol (Stilbestrol), methyltestosterone, desoxycorticosterone acetate, adrenal cortex extract, and chorionic gonadotropin. 2 The purpose of this paper is (a) to report seven patients in whom gynecomastia developed in conjunction with generalized dermatologic disorders, (b) to discuss briefly the etiology of gynecomastia, and (c) to consider the significance of gynecomastia when it occurs in association with generalized cutaneous diseases. REPORT OF CASES Case1.— Generalized Atopic Dermatitis This patient, a white man, had atopic dermatitis during the summer months only when between the ages of 9 and

Published
1953

2. Stress studies in the eczema-asthma-hay-fever diathesis

Author

Murray C. Zimmerman and Thomas H. Sternberg

Subjects
medicine.medical_specialty, business.industry, Eczema, Rhinitis, Allergic, Seasonal, Dermatology, General Medicine, Emotional stress, Atopic dermatitis, Atopic diathesis, Diathesis, medicine.disease, Asthma, Stress studies, medicine, Hypersensitivity, Hay fever, Humans, Disease Susceptibility, medicine.symptom, business, Alarm reaction
Abstract

IN A PREVIOUS paper1we reported the effects of an artificially applied stress situation on the "alarm reaction" response of persons with the skin component of the eczema-asthma-hay-fever complex (atopic dermatitis). While the number of patients studied was small, there were definite indications of an abnormal response, as measured by the eosinopenic index and changes in the lymphocyteneutrophile ratio. Our results supported Selye's concept2that the allergic or atopic diathesis should be included in the so-called diseases of adaptation. This concept holds that these diseases may depend largely upon a derangement of the pituitary-adrenocortical response to stress, and, further, that as for "triggering" the alarm reaction, there is little or no difference between physical and psychic or emotional stress. In this paper we are reporting a continuation of our previous studies. Both our control and experimental groups have been considerably expanded. The alarm-reaction response, as

Published
1952