1. Neurological complications following the use of efocaine
- Author
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Helen E. Hall, William K. Nowill, and C. Ronald Stephen
- Subjects
Drug ,medicine.medical_specialty ,Necrosis ,business.industry ,Local anesthetic ,medicine.drug_class ,media_common.quotation_subject ,Regeneration (biology) ,Neuritis ,Connective tissue ,Neuroma ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Anesthesia ,medicine ,Aminobenzoates ,medicine.symptom ,Nervous System Diseases ,business ,Procaine ,Medical literature ,media_common - Abstract
MANY FAVORABLE reports on the use of Efocaine 1 as a long-acting local anesthetic drug have been published in the past two years. 2 Studies of histological changes following the injection of this drug in various animals have been reported previously by us. 3 These changes may be summarized as follows: necrosis of muscle followed by regeneration and connective tissue proliferation; nerve destruction of varying degrees of severity, the repair of which may be associated with neuroma formation. It is not unexpected, therefore, to see reports of complications associated with the use of this drug appear in the medical literature. Bonica 4 noted 6 cases of postinjection neuritis in 100 cases in which this drug was used. Eastwood and Bartlett 5 recently stated that they have discontinued the clinical use of Efocaine because of similar complications. Shapiro and Norman 6 reported three serious complications following the injection of this drug
- Published
- 1953