18 results on '"Maniruzzaman"'
Search Results
2. Comparison of HPMC Inhalation-Grade Capsules and Their Effect on Aerosol Performance Using Budesonide and Rifampicin DPI Formulations
- Author
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Li, Ding, Ashlee D, Brunaugh, Rishi, Thakkar, Christian, Lee, Qingyan Jenny, Zhao, Justin, Kalafat, Mohammed, Maniruzzaman, and Hugh D C, Smyth
- Subjects
Aerosols ,Ecology ,Chemistry, Pharmaceutical ,Hydroxypropyl methylcellulose ,Pharmaceutical Science ,Capsules ,Dry Powder Inhalers ,General Medicine ,Aquatic Science ,Pulmonary drug delivery ,Hypromellose Derivatives ,Inhalation capsule ,Administration, Inhalation ,Drug Discovery ,Aerosol performance ,Particle Size ,Powders ,Rifampin ,Budesonide ,Agronomy and Crop Science ,Ecology, Evolution, Behavior and Systematics ,Research Article - Abstract
Despite the fact that capsules play an important role in many dry powder inhalation (DPI) systems, few studies have been conducted to investigate the capsules’ interactions with respirable powders. The effect of four commercially available hydroxypropyl methylcellulose (HPMC)inhalation-grade capsule types on the aerosol performance of two model DPI formulations (lactose carrier and a carrier-free formulation) at two different pressure drops was investigated in this study. There were no statistically significant differences in performance between capsules by using the carrier-based formulation. However, there were some differences between the capsules used for the carrier-free rifampicin formulation. At 2-kPa pressure drop conditions, Embocaps® VG capsules had a higher mean emitted fraction (EF) (89.86%) and a lower mean mass median aerodynamic diameter (MMAD) (4.19 µm) than Vcaps® (Capsugel) (85.54%, 5.10 µm) and Quali-V® I (Qualicaps) (85.01%, 5.09 µm), but no significant performance differences between Embocaps® and ACGcaps™ HI. Moreover, Embocaps® VG capsules exhibited a higher mean respirable fraction (RF)/fine particle fraction (FPF) with a 3-µm–sized cutoff (RF/FPF< 3 µm) (33.05%/35.36%) against Quali-V® I (28.16%/31.75%) (P
- Published
- 2022
3. Comparison of HPMC Inhalation-Grade Capsules and Their Effect on Aerosol Performance Using Budesonide and Rifampicin DPI Formulations
- Author
-
Ding, Li, primary, Brunaugh, Ashlee D., additional, Thakkar, Rishi, additional, Lee, Christian, additional, Zhao, Qingyan Jenny, additional, Kalafat, Justin, additional, Maniruzzaman, Mohammed, additional, and Smyth, Hugh D. C., additional
- Published
- 2022
- Full Text
- View/download PDF
4. Fabrication of Sustained-Release Dosages Using Powder-Based Three-Dimensional (3D) Printing Technology.
- Author
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Giri, Bhupendra Raj and Maniruzzaman, Mohammed
- Abstract
Three-dimensional (3D)-printed tablets prepared using powder-based printing techniques like selective laser sintering (SLS) typically disintegrate/dissolve and release the drug within a few minutes because of their inherent porous nature and loose structure. The goal of this study was to demonstrate the suitability of SLS 3DP technology for fabricating sustained-release dosages utilizing Kollidon
® SR (KSR), a matrix-forming excipient composed of polyvinyl acetate and polyvinylpyrrolidone (8:2). A physical mixture (PM), comprising 10:85:5 (% w/w) of acetaminophen (ACH), KSR, and Candurin® , was sintered using a benchtop SLS 3D printer equipped with a 2.3-W 455-nm blue visible laser. After optimization of the process parameters and formulation composition, robust 3D-printed tablets were obtained as per the computer-aided design (CAD) model. Advanced solid-state characterizations by powder X-ray diffraction (PXRD) and wide-angle X-ray scattering (WAXS) confirmed that ACH remained in its native crystalline state after sintering. In addition, X-ray micro-computed tomography (micro-CT) studies revealed that the tablets contain a total porosity of 57.7% with an average pore diameter of 24.8 μm. Moreover, SEM images exhibited a morphological representation of the ACH sintered tablets' exterior surface. Furthermore, the KSR matrix 3D-printed tablets showed a sustained-release profile, releasing roughly 90% of the ACH over 12 h as opposed to a burst release from the free drug and PM. Overall, our work shows for the first time that KSR can be used as a suitable polymer matrix to create sustained-release dosage forms utilizing the digitally controllable SLS 3DP technology, showcasing an alternative technique and pharmaceutical excipient. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
5. Investigation of the Fused Deposition Modeling Additive Manufacturing I: Influence of Process Temperature on the Quality and Crystallinity of the Dosage Forms
- Author
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Zhang, Jiaxiang, primary, Thakkar, Rishi, additional, Kulkarni, Vineet R., additional, Zhang, Yu, additional, Lu, Anqi, additional, and Maniruzzaman, Mohammed, additional
- Published
- 2021
- Full Text
- View/download PDF
6. Investigation of the Fused Deposition Modeling Additive Manufacturing I: Influence of Process Temperature on the Quality and Crystallinity of the Dosage Forms
- Author
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Mohammed Maniruzzaman, Jiaxiang Zhang, Anqi Lu, Vineet Kulkarni, Yu Zhang, and Rishi Thakkar
- Subjects
Materials science ,Pharmaceutical Science ,3D printing ,Aquatic Science ,Slicing ,Dosage form ,law.invention ,Excipients ,Crystallinity ,law ,Drug Discovery ,Humans ,Technology, Pharmaceutical ,Process engineering ,Ecology, Evolution, Behavior and Systematics ,Ecology ,Fused deposition modeling ,business.industry ,Temperature ,Reproducibility of Results ,General Medicine ,Drug Liberation ,Drug development ,Scientific method ,Drug delivery ,Printing, Three-Dimensional ,business ,Agronomy and Crop Science ,Tablets - Abstract
With the advancements in cutting-edge technologies and rapid development of medical sciences, patient-focused drug development (PFDD) through additive manufacturing (AM) processes is gathering more interest in the pharmaceutical area than ever. Hence, there is an urgent need for researchers to comprehensively understand the influence of three-dimensional design on the development of novel drug delivery systems (DDSs). For this research, fused deposition modeling (FDM) 3D printing was investigated, and phenytoin (PHT) was selected as the model drug. The primary purpose of the current investigation was to understand the influence of AM process on the pharmaceutical products' quality. A series of comparative studies, including morphology, solid-state analysis, and in vitro drug release studies between additive manufactured filaments (printlets) and extruded filaments, were conducted. The FDM-based AM showed adequate reproducibility by manufacturing printlets with consistent qualities; however, the model slicing orientation significantly affected the print qualities. The texture analysis studies showed that the mechanical properties (breaking behavior) of additive manufactured printlets were varied from the extruded filaments. Additionally, the higher printing temperature also influenced the solid state of the drug where the process assisted in PHT's amorphization in the printed products, which further affected their mechanical properties and in vitro drug release performances. The current investigation illustrated that the AM process would change the printed objects' macrostructure over the conventional products, and the printing temperature and slicing will significantly affect the printing process and product qualities.
- Published
- 2021
7. Retraction Note: Study of the Transformations of Micro/Nano-crystalline Acetaminophen Polymorphs in Drug-Polymer Binary Mixtures
- Author
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Carlos Molina, Ali Nokhodchi, Mohammed Maniruzzaman, and Matthew Lam
- Subjects
Pyrrolidines ,Vinyl Compounds ,Materials science ,Pharmaceutical Science ,Aquatic Science ,Crystallography, X-Ray ,chemistry.chemical_compound ,Differential scanning calorimetry ,Drug Stability ,Polymethacrylic Acids ,X-Ray Diffraction ,Drug Discovery ,Copolymer ,Vinyl acetate ,Thermal stability ,Ecology, Evolution, Behavior and Systematics ,Acetaminophen ,chemistry.chemical_classification ,Drug Carriers ,Calorimetry, Differential Scanning ,Ecology ,Temperature ,technology, industry, and agriculture ,Povidone ,General Medicine ,Polymer ,Analgesics, Non-Narcotic ,Retraction Note ,chemistry ,Chemical engineering ,Polymorphism (materials science) ,Nanoparticles ,Orthorhombic crystal system ,Crystallization ,Hydrophobic and Hydrophilic Interactions ,Agronomy and Crop Science ,Monoclinic crystal system - Abstract
This study elucidates the physical properties of sono-crystallised micro/nano-sized acetaminophen/paracetamol (PMOL) and monitors its possible transformation from polymorphic form I (monoclinic) to form II (orthorhombic). Hydrophilic Plasdone® S630 copovidone (S630), N-vinyl-2-pyrrolidone and vinyl acetate copolymer, and methacrylate-based cationic copolymer, Eudragit® EPO (EPO), were used as polymeric carriers to prepare drug/polymer binary mixtures. Commercially available PMOL was crystallised under ultra sound sonication to produce micro/nano-sized (0.2–10 microns) crystals in monoclinic form. Homogeneous binary blends of drug-polymer mixtures at various drug concentrations were obtained via a thorough mixing. The analysis conducted via the single X-ray crystallography determined the detailed structure of the crystallised PMOL in its monoclinic form. The solid state and the morphology analyses of the PMOL in the binary blends evaluated via differential scanning calorimetry (DSC), modulated temperature DSC (MTDSC), scanning electron microscopy (SEM) and hot stage microscopy (HSM) revealed the crystalline existence of the drug within the amorphous polymeric matrices. The application of temperature controlled X-ray diffraction (VTXRPD) to study the polymorphism of PMOL showed that the most stable form I (monoclinic) was altered to its less stable form II (orthorhombic) at high temperature (>112°C) in the binary blends regardless of the drug amount. Thus, VTXRD was used as a useful tool to monitor polymorphic transformations of crystalline drug (e.g. PMOL) to assess their thermal stability in terms of pharmaceutical product development and research.
- Published
- 2020
8. Retraction Note: Study of the Transformations of Micro/Nano-crystalline Acetaminophen Polymorphs in Drug-Polymer Binary Mixtures
- Author
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Maniruzzaman, Mohammed, primary, Lam, Matthew, additional, Molina, Carlos, additional, and Nokhodchi, Ali, additional
- Published
- 2020
- Full Text
- View/download PDF
9. RETRACTED ARTICLE: Study of the Transformations of Micro/Nano-crystalline Acetaminophen Polymorphs in Drug-Polymer Binary Mixtures
- Author
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Carlos Molina, Matthew Lam, Ali Nokhodchi, and Mohammed Maniruzzaman
- Subjects
Materials science ,Pharmaceutical Science ,02 engineering and technology ,Aquatic Science ,030226 pharmacology & pharmacy ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Differential scanning calorimetry ,Drug Discovery ,Copolymer ,Vinyl acetate ,Thermal stability ,Ecology, Evolution, Behavior and Systematics ,chemistry.chemical_classification ,Ecology ,technology, industry, and agriculture ,General Medicine ,Polymer ,021001 nanoscience & nanotechnology ,Crystallography ,Chemical engineering ,Polymorphism (materials science) ,chemistry ,Orthorhombic crystal system ,0210 nano-technology ,Agronomy and Crop Science ,Monoclinic crystal system - Abstract
This study elucidates the physical properties of sono-crystallised micro/nano-sized acetaminophen/paracetamol (PMOL) and monitors its possible transformation from polymorphic form I (monoclinic) to form II (orthorhombic). Hydrophilic Plasdone® S630 copovidone (S630), N-vinyl-2-pyrrolidone and vinyl acetate copolymer, and methacrylate-based cationic copolymer, Eudragit® EPO (EPO), were used as polymeric carriers to prepare drug/polymer binary mixtures. Commercially available PMOL was crystallised under ultra sound sonication to produce micro/nano-sized (0.2–10 microns) crystals in monoclinic form. Homogeneous binary blends of drug-polymer mixtures at various drug concentrations were obtained via a thorough mixing. The analysis conducted via the single X-ray crystallography determined the detailed structure of the crystallised PMOL in its monoclinic form. The solid state and the morphology analyses of the PMOL in the binary blends evaluated via differential scanning calorimetry (DSC), modulated temperature DSC (MTDSC), scanning electron microscopy (SEM) and hot stage microscopy (HSM) revealed the crystalline existence of the drug within the amorphous polymeric matrices. The application of temperature controlled X-ray diffraction (VTXRPD) to study the polymorphism of PMOL showed that the most stable form I (monoclinic) was altered to its less stable form II (orthorhombic) at high temperature (>112°C) in the binary blends regardless of the drug amount. Thus, VTXRD was used as a useful tool to monitor polymorphic transformations of crystalline drug (e.g. PMOL) to assess their thermal stability in terms of pharmaceutical product development and research.
- Published
- 2016
10. Novel Controlled Release Polymer-Lipid Formulations Processed by Hot Melt Extrusion
- Author
-
Devyani Amin, Muhammad T. Islam, Dennis Douroumis, Sheelagh A. Halsey, and Mohammed Maniruzzaman
- Subjects
Hot Temperature ,Polymers ,Chemistry, Pharmaceutical ,Drug Compounding ,Indomethacin ,Pharmaceutical Science ,02 engineering and technology ,Methylcellulose ,Aquatic Science ,030226 pharmacology & pharmacy ,Glycerides ,Polyethylene Glycols ,Fats ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Differential scanning calorimetry ,X-Ray Diffraction ,Drug Discovery ,Organic chemistry ,Solubility ,Dissolution ,Ecology, Evolution, Behavior and Systematics ,chemistry.chemical_classification ,Drug Carriers ,Calorimetry, Differential Scanning ,Ecology ,General Medicine ,Polymer ,Hydrogen-Ion Concentration ,021001 nanoscience & nanotechnology ,Lipids ,Controlled release ,chemistry ,Chemical engineering ,Delayed-Action Preparations ,Methyl cellulose ,Extrusion ,0210 nano-technology ,Drug carrier ,Hydrophobic and Hydrophilic Interactions ,Oils ,Agronomy and Crop Science ,Research Article - Abstract
The aim of the study was to investigate the effect of novel polymer/lipid formulations on the dissolution rates of the water insoluble indomethacin (INM), co-processed by hot melt extrusion (HME). Formulations consisted of the hydrophilic hydroxypropyl methyl cellulose polymer (HPMCAS) and stearoyl macrogol-32 glycerides—Gelucire 50/13 (GLC) were processed with a twin screw extruder to produce solid dispersions. The extrudates characterized by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and hot stage microscopy (HSM) indicated the presence of amorphous INM within the polymer/lipid matrices. In-line monitoring via near-infrared (NIR) spectroscopy revealed significant peak shifts indicating possible interactions and H-bonding formation between the drug and the polymer/lipid carriers. Furthermore, in vitro dissolution studies showed a synergistic effect of the polymer/lipid carrier with 2-h lag time in acidic media followed by enhanced INM dissolution rates at pH > 5.5.
- Published
- 2015
11. Development and Optimisation of Spironolactone Nanoparticles for Enhanced Dissolution Rates and Stability
- Author
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Kelidari, H. R., primary, Saeedi, M., additional, Akbari, J., additional, Morteza-semnani, K., additional, Valizadeh, H., additional, Maniruzzaman, Mohammed, additional, Farmoudeh, Ali, additional, and Nokhodchi, Ali, additional
- Published
- 2016
- Full Text
- View/download PDF
12. RETRACTED ARTICLE: Study of the Transformations of Micro/Nano-crystalline Acetaminophen Polymorphs in Drug-Polymer Binary Mixtures
- Author
-
Maniruzzaman, Mohammed, primary, Lam, Matthew, additional, Molina, Carlos, additional, and Nokhodchi, Ali, additional
- Published
- 2016
- Full Text
- View/download PDF
13. Novel Controlled Release Polymer-Lipid Formulations Processed by Hot Melt Extrusion
- Author
-
Maniruzzaman, Mohammed, primary, Islam, Muhammad T., additional, Halsey, Sheelagh, additional, Amin, Devyani, additional, and Douroumis, Dennis, additional
- Published
- 2015
- Full Text
- View/download PDF
14. Development and Optimisation of Spironolactone Nanoparticles for Enhanced Dissolution Rates and Stability.
- Author
-
Kelidari, H., Saeedi, M., Akbari, J., Morteza-semnani, K., Valizadeh, H., Maniruzzaman, Mohammed, Farmoudeh, Ali, and Nokhodchi, Ali
- Abstract
Stable solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) formulations to enhance the dissolution rates of poorly soluble drug spironolactone (SP) were being developed. Probe ultra-sonication method was used to prepare SLNs and NLCs. All NLCs contained stearic acid (solid lipid carrier) and oleic acid (liquid lipid content), whereas, SLNs were prepared and optimised by using the solid lipid only. The particles were characterised in terms of particle size analysis, thermal behaviour, morphology, stability and in vitro release. The zeta sizer data revealed that the increase in the concentration of oleic acid in the formulations reduced the mean particle size and the zeta potential. The increase in concentration of oleic acid from 0 to 30% ( w/ w) resulted in a higher entrapment efficiency. All nanoparticles were almost spherically shaped with an average particle size of about ∼170 nm. The DSC traces revealed that the presence of oleic acid in the NLC formulations resulted in a shift in the melting endotherms to a higher temperature. This could be attributed to a good long-term stability of the nanoparticles. The stability results showed that the particle size remained smaller in NLC compared to that of SLN formulations after 6 months at various temperatures. The dissolution study showed about a 5.1- to 7.2-fold increase in the release of the drug in 2 h compared to the raw drug. Comparing all nanoparticle formulations indicated that the NLC composition with a ratio of 70:30 (solid:liquid lipid) is the most suitable formulation with desired drug dissolution rates, entrapment efficiency and physical stability. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
15. Study of the Transformations of Micro/Nano-crystalline Acetaminophen Polymorphs in Drug-Polymer Binary Mixtures.
- Author
-
Maniruzzaman, Mohammed, Lam, Matthew, Molina, Carlos, and Nokhodchi, Ali
- Abstract
This study elucidates the physical properties of sono-crystallised micro/nano-sized acetaminophen/paracetamol (PMOL) and monitors its possible transformation from polymorphic form I (monoclinic) to form II (orthorhombic). Hydrophilic Plasdone® S630 copovidone (S630), N-vinyl-2-pyrrolidone and vinyl acetate copolymer, and methacrylate-based cationic copolymer, Eudragit® EPO (EPO), were used as polymeric carriers to prepare drug/polymer binary mixtures. Commercially available PMOL was crystallised under ultra sound sonication to produce micro/nano-sized (0.2-10 microns) crystals in monoclinic form. Homogeneous binary blends of drug-polymer mixtures at various drug concentrations were obtained via a thorough mixing. The analysis conducted via the single X-ray crystallography determined the detailed structure of the crystallised PMOL in its monoclinic form. The solid state and the morphology analyses of the PMOL in the binary blends evaluated via differential scanning calorimetry (DSC), modulated temperature DSC (MTDSC), scanning electron microscopy (SEM) and hot stage microscopy (HSM) revealed the crystalline existence of the drug within the amorphous polymeric matrices. The application of temperature controlled X-ray diffraction (VTXRPD) to study the polymorphism of PMOL showed that the most stable form I (monoclinic) was altered to its less stable form II (orthorhombic) at high temperature (>112°C) in the binary blends regardless of the drug amount. Thus, VTXRD was used as a useful tool to monitor polymorphic transformations of crystalline drug (e.g. PMOL) to assess their thermal stability in terms of pharmaceutical product development and research. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
16. Novel Controlled Release Polymer-Lipid Formulations Processed by Hot Melt Extrusion.
- Author
-
Maniruzzaman, Mohammed, Islam, Muhammad, Halsey, Sheelagh, Amin, Devyani, and Douroumis, Dennis
- Abstract
The aim of the study was to investigate the effect of novel polymer/lipid formulations on the dissolution rates of the water insoluble indomethacin (INM), co-processed by hot melt extrusion (HME). Formulations consisted of the hydrophilic hydroxypropyl methyl cellulose polymer (HPMCAS) and stearoyl macrogol-32 glycerides-Gelucire 50/13 (GLC) were processed with a twin screw extruder to produce solid dispersions. The extrudates characterized by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and hot stage microscopy (HSM) indicated the presence of amorphous INM within the polymer/lipid matrices. In-line monitoring via near-infrared (NIR) spectroscopy revealed significant peak shifts indicating possible interactions and H-bonding formation between the drug and the polymer/lipid carriers. Furthermore, in vitro dissolution studies showed a synergistic effect of the polymer/lipid carrier with 2-h lag time in acidic media followed by enhanced INM dissolution rates at pH > 5.5. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
17. Study of the Transformations of Micro/Nano-crystalline Acetaminophen Polymorphs in Drug-Polymer Binary Mixtures
- Author
-
Maniruzzaman, Mohammed, Lam, Matthew, Molina, Carlos, and Nokhodchi, Ali
- Subjects
monoclinic ,sono-crystallisation ,variable temperature XRPD ,nano-sized crystals ,technology, industry, and agriculture ,Pharmaceutical Science ,orthorhombic ,Research Article - Abstract
This study elucidates the physical properties of sono-crystallised micro/nano-sized acetaminophen/paracetamol (PMOL) and monitors its possible transformation from polymorphic form I (monoclinic) to form II (orthorhombic). Hydrophilic Plasdone® S630 copovidone (S630), N-vinyl-2-pyrrolidone and vinyl acetate copolymer, and methacrylate-based cationic copolymer, Eudragit® EPO (EPO), were used as polymeric carriers to prepare drug/polymer binary mixtures. Commercially available PMOL was crystallised under ultra sound sonication to produce micro/nano-sized (0.2–10 microns) crystals in monoclinic form. Homogeneous binary blends of drug-polymer mixtures at various drug concentrations were obtained via a thorough mixing. The analysis conducted via the single X-ray crystallography determined the detailed structure of the crystallised PMOL in its monoclinic form. The solid state and the morphology analyses of the PMOL in the binary blends evaluated via differential scanning calorimetry (DSC), modulated temperature DSC (MTDSC), scanning electron microscopy (SEM) and hot stage microscopy (HSM) revealed the crystalline existence of the drug within the amorphous polymeric matrices. The application of temperature controlled X-ray diffraction (VTXRPD) to study the polymorphism of PMOL showed that the most stable form I (monoclinic) was altered to its less stable form II (orthorhombic) at high temperature (>112°C) in the binary blends regardless of the drug amount. Thus, VTXRD was used as a useful tool to monitor polymorphic transformations of crystalline drug (e.g. PMOL) to assess their thermal stability in terms of pharmaceutical product development and research.
- Full Text
- View/download PDF
18. Development and Optimisation of Spironolactone Nanoparticles for Enhanced Dissolution Rates and Stability
- Author
-
Ali Nokhodchi, Hadi Valizadeh, Ali Farmoudeh, Mohammed Maniruzzaman, Majid Saeedi, K. Morteza-Semnani, Jafar Akbari, and Hamid Reza Kelidari
- Subjects
Nanoparticle ,Pharmaceutical Science ,02 engineering and technology ,Spironolactone ,Aquatic Science ,030226 pharmacology & pharmacy ,03 medical and health sciences ,chemistry.chemical_compound ,Drug Delivery Systems ,0302 clinical medicine ,Drug Stability ,Drug Discovery ,Solid lipid nanoparticle ,Zeta potential ,Dissolution testing ,Particle Size ,Dissolution ,Ecology, Evolution, Behavior and Systematics ,Drug Carriers ,Chromatography ,Ecology ,General Medicine ,021001 nanoscience & nanotechnology ,Drug Liberation ,Oleic acid ,Solubility ,chemistry ,Chemical engineering ,Nanoparticles ,lipids (amino acids, peptides, and proteins) ,Stearic acid ,Particle size ,0210 nano-technology ,Agronomy and Crop Science ,Stearic Acids - Abstract
Stable solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) formulations to enhance the dissolution rates of poorly soluble drug spironolactone (SP) were being developed. Probe ultra-sonication method was used to prepare SLNs and NLCs. All NLCs contained stearic acid (solid lipid carrier) and oleic acid (liquid lipid content), whereas, SLNs were prepared and optimised by using the solid lipid only. The particles were characterised in terms of particle size analysis, thermal behaviour, morphology, stability and in vitro release. The zeta sizer data revealed that the increase in the concentration of oleic acid in the formulations reduced the mean particle size and the zeta potential. The increase in concentration of oleic acid from 0 to 30% (w/w) resulted in a higher entrapment efficiency. All nanoparticles were almost spherically shaped with an average particle size of about ∼170 nm. The DSC traces revealed that the presence of oleic acid in the NLC formulations resulted in a shift in the melting endotherms to a higher temperature. This could be attributed to a good long-term stability of the nanoparticles. The stability results showed that the particle size remained smaller in NLC compared to that of SLN formulations after 6 months at various temperatures. The dissolution study showed about a 5.1- to 7.2-fold increase in the release of the drug in 2 h compared to the raw drug. Comparing all nanoparticle formulations indicated that the NLC composition with a ratio of 70:30 (solid:liquid lipid) is the most suitable formulation with desired drug dissolution rates, entrapment efficiency and physical stability.
- Full Text
- View/download PDF
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