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Start Over Author "Wang, Shige" Journal acs applied materials & interfaces
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7. Integration of Fe3O4with Bi2S3for Multi-Modality Tumor Theranostics

Author

Luo, Keyi, Zhao, Jiulong, Jia, Chengzheng, Chen, Yongkang, Zhang, Zhilun, Zhang, Jing, Huang, Mingxian, and Wang, Shige

Abstract

The combination of reactive oxygen species (ROS)-induced chemodynamic therapy (CDT) and photothermal therapy (PTT) holds a promising application prospect for their superb anticancer efficiency. Herein, we created a novel Fe3O4@polydopamine (PDA)@bovine serum albumin (BSA)-Bi2S3composite as a theranostic agent, by chemically linking the Fe3O4@PDA with BSA-Bi2S3via the amidation between the carboxyl groups of BSA and the amino groups of PDA. In this formulation, the Fe3O4NPs could not only work as a mimetic peroxidase to trigger Fenton reactions of the innate H2O2in the tumor and generate highly cytotoxic hydroxyl radicals (•OH) to induce tumor apoptosis but also serve as the magnetic resonance imaging (MRI) contrast agent to afford the precise cancer diagnosis. Meanwhile, the PDA could prevent the oxidization of Fe3O4, thus supporting the long-term Fenton reactions and the tumor apoptosis in the tumor. The Bi2S3component exhibits excellent photothermal transducing performance and computed tomography (CT) imaging capacity. In addition, the PDA and Bi2S3endow the Fe3O4@PDA@BSA-Bi2S3composite with an excellent photothermal transforming ability which could lead to tumor hyperthermia. All of these merits play the synergism with the tumor microenvironment and qualify the Fe3O4@PDA@BSA-Bi2S3NPs for a competent agent in the MRI/CT-monitored enhanced PTT/CDT synergistic therapy. Findings in this research will evoke new interests in future cancer therapeutic strategies based on biocompatible nanomaterials.

Published
2020
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