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1. Biomineralized Cascade Enzyme-Encapsulated ZIF-8 Nanoparticles Combined with Antisense Oligonucleotides for Drug-Resistant Bacteria Treatment

Author

Yan Zhang, Luogen Lai, Yijun Liu, Beini Chen, Jing Yao, Pengwu Zheng, Qingshan Pan, and Wufu Zhu

Subjects
Methicillin-Resistant Staphylococcus aureus, Staphylococcus aureus, Hydroxyl Radical, Imidazoles, Microbial Sensitivity Tests, Oligonucleotides, Antisense, Staphylococcal Infections, Skin Diseases, Cytoskeletal Proteins, Glucose Oxidase, Mice, Bacterial Proteins, Biofilms, Escherichia coli, Animals, Nanoparticles, General Materials Science, Reactive Oxygen Species, Horseradish Peroxidase, Metal-Organic Frameworks
Abstract

The unrestrained use of antibiotics accelerates the development of drug-resistant bacteria and leads to an increasing threat to human health. Therefore, there is an urgent need to explore novel and effective strategies for the treatment of bacterial infections. Herein, zeolite imidazole framework-8 (ZIF-8) material was utilized to construct biomineralized nanomaterial (GOxHRP@ZIF-8/ASO) by encapsulating biological cascade enzymes and combining with antisense oligonucleotides (ASOs), which achieved effective and synergistic antidrug-resistant bacteria therapy. Various

Published
2022

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