1. Gold-Nanobipyramid-Based Nanotheranostics for Dual-Modality Imaging-Guided Phototherapy
- Author
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Zhiming Li, Peng Huang, Yashi Li, Liyue Hou, Bhawneeta Nugasur, Yun Yang, Chunxiao Li, Xiaoxia Ding, Jing Lin, Enci Mei, Murong Hu, Cunguo Chen, Yifan Zhang, and Zhongqian Su
- Subjects
Indocyanine Green ,Materials science ,genetic structures ,Cell Survival ,Metal Nanoparticles ,Antineoplastic Agents ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Multimodal Imaging ,Theranostic Nanomedicine ,chemistry.chemical_compound ,Mice ,Cell Line, Tumor ,medicine ,Animals ,Humans ,General Materials Science ,Fluorescent Dyes ,Optical Imaging ,Cancer ,Mesoporous silica ,Photothermal therapy ,Phototherapy ,021001 nanoscience & nanotechnology ,medicine.disease ,Tumor tissue ,0104 chemical sciences ,Tumor recurrence ,chemistry ,Cancer cell ,Dual modality ,Gold ,0210 nano-technology ,Indocyanine green ,Biomedical engineering - Abstract
Multimodality imaging-guided therapy can improve the diagnostics and therapeutics efficiency of cancer. Herein, we developed a light-responsive nanotheranostic agent based on the indocyanine green (ICG) conjugated mesoporous silica coated gold nanobipyramid (GNB@SiO2) (denoted as GNB@SiO2-ICG) for simultaneous fluorescence (FL)/photoacoustic (PA) imaging-guided photothermal therapy (PTT). The GNB@SiO2 with excellent photostability was used for PA imaging as well as PTT. The loaded ICG promised FL imaging and PTT. The feasibility of the cancer theranostic capability of GNB@SiO2-ICG was evaluated from cancer cells to mice. Under the guidance of FL/PA imaging, GNB@SiO2-ICG exhibited remarkably enhanced therapeutic efficacy, which could eliminate the tumor tissues completely without tumor recurrence. This well-defined nanotheranostic nanoplatform that intelligently integrates dual-modality imaging and phototherapy provides an efficient nanoplatform for cancer nanotheranostics.
- Published
- 2020