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Your search keyword '"Minhuan Lan"' showing total 3 results
Start Over Author "Minhuan Lan" Journal acs applied materialsinterfaces
3 results on '"Minhuan Lan"'

1. A-DA'D-A Structured Organic Phototheranostics for NIR-II Fluorescence/Photoacoustic Imaging-Guided Photothermal and Photodynamic Synergistic Therapy

Author

Ke Yang, Fei Long, Wei Liu, Zequn Zhang, Shaojing Zhao, Benhua Wang, Yingping Zou, Minhuan Lan, Jun Yuan, Xiangzhi Song, and Changwei Lin

Subjects
Photoacoustic Techniques, Photochemotherapy, Cell Line, Tumor, Optical Imaging, Nanoparticles, General Materials Science, Phototherapy, Theranostic Nanomedicine
Abstract

Multimodal imaging-guided combinational phototherapies triggered by a single near-infrared (NIR) laser are highly desirable. However, their development is still a big challenge. Herein, we have developed an "acceptor-donor-acceptor'-donor-acceptor" structured organic phototheranostics (Y16-Pr) with strong light-harvesting ability in the NIR region. After being modified with polyethylene glycol (PEG), the obtained biocompatible nanoparticles (Y16-Pr-PEG NPs) could conduct NIR-II fluorescence imaging (FLI) and photoacoustic imaging (PAI) and perform photothermal therapy (PTT) and photodynamic therapy (PDT) simultaneously. Notably, Y16-Pr-PEG NPs showed an impressive photothermal conversion efficiency (PCE) of 82.4% under 808 nm laser irradiation. The irradiated NPs could also produce hydroxyl radicals (•OH) and singlet oxygen (

Published
2022

2. Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer

Author

Guangle Niu, Liang Guo, Hongyan Zhang, Junfang Zhao, Minhuan Lan, Pengfei Wang, Hongyan Sun, Weimin Liu, Yusheng Xie, Jinyuan Zhang, Ying Li, Shaojing Zhao, and Wenjun Zhang

Subjects
Fluorescence-lifetime imaging microscopy, Materials science, Biocompatibility, Polymers, medicine.medical_treatment, Nanoparticle, Photodynamic therapy, 02 engineering and technology, Thiophenes, 010402 general chemistry, Photochemistry, 01 natural sciences, Fluorescence, chemistry.chemical_compound, Two-photon excitation microscopy, Neoplasms, medicine, Humans, General Materials Science, chemistry.chemical_classification, Photons, Photosensitizing Agents, Biomolecule, Water, 021001 nanoscience & nanotechnology, 0104 chemical sciences, chemistry, Photochemotherapy, Polythiophene, 0210 nano-technology
Abstract

Positively charged water-soluble polythiophene (PT0) that could self-assemble into nanoparticles in pure water solution was designed and synthesized. PT0 exhibited high photostabilities and pH stabilities, excellent biocompatibility, strong 1O2 generation capability, and large two-photon absorption cross sections. Moreover, we showed that the fluorescence of PT0 was unaffected by the interference of biomolecules and metal ions. As an example application, PT0 was demonstrated to be capable of simultaneous cell imaging and photodynamic therapy under either one-photon or two-photon excitation modes.

Published
2017

3. Near-Infrared Organic Dye-Based Nanoagent for the Photothermal Therapy of Cancer

Author

Yunzheng Li, Guangle Niu, Qingyan Jia, Bingjiang Zhou, Minhuan Lan, and Qionglin Liang

Subjects
Materials science, Biocompatibility, Analytical chemistry, Quantum yield, Nanoparticle, 02 engineering and technology, 010402 general chemistry, Photochemistry, 01 natural sciences, Rhodamine, chemistry.chemical_compound, Mice, Neoplasms, Animals, General Materials Science, Cyanine, Coloring Agents, technology, industry, and agriculture, Serum Albumin, Bovine, Photothermal therapy, Molar absorptivity, Phototherapy, 021001 nanoscience & nanotechnology, Fluorescence, 0104 chemical sciences, chemistry, Nanoparticles, 0210 nano-technology
Abstract

Given their easy structural modification and good biocompatibility advantages, near-infrared (NIR) organic dyes with a large molar extinction coefficient, while a superlow fluorescence quantum yield shows considerable potential application in photothermal therapy (PTT). Herein, a new NIR-absorbing asymmetric cyanine dye, namely, RC, is designed and synthesized via the hybrid of rhodamine and hemicyanine derivatives. RC-BSA nanoparticles (NPs) are fabricated by using the bovine serum albumin (BSA) matrix. The NPs exhibit a strong NIR absorption peak at ∼868 nm and 28.7% photothermal conversion efficiency. Based on these features, RC-BSA NPs exhibit excellent performance in ablating tumor under a 915 nm laser radiation through a PTT mechanism. These NPs show no obvious toxicity to the treated mice. Thus, RC-BSA NPs can used as a new NIR laser-triggered PTT agent in cancer treatment.

Published
2016

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