1. H
- Author
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Kun-Ying, Lu, Po-Yen, Lin, Er-Yuan, Chuang, Chwen-Ming, Shih, Tsai-Mu, Cheng, Tsung-Yao, Lin, Hsing-Wen, Sung, and Fwu-Long, Mi
- Subjects
Oxygen ,Selenium ,Macrophages ,Nanoparticles ,Hydrogen Peroxide ,Fluorescence - Abstract
Macrophages have a pivotal role in chronic inflammatory diseases (CIDs), so imaging and controlling activated macrophage is critical for detecting and reducing chronic inflammation. In this study, photodynamic selenium nanoparticles (SeNPs) with photosensitive and macrophage-targeting bilayers were developed. The first layer of the photosensitive macromolecule was composed of a conjugate of a photosensitizer (rose bengal, RB) and a thiolated chitosan (chitosan-glutathione), resulting in a plasmonic coupling-induced red shift and broadening of RB absorption bands with increased absorption intensity. Electron paramagnetic resonance (EPR) and diphenylanthracene (DPA) quenching studies revealed that the SeNPs that were coated with the photosensitive layer were more effective than RB alone in producing singlet oxygen (
- Published
- 2017