1. A Biomimetic Zinc Alloy Scaffold Coated with Brushite for Enhanced Cranial Bone Regeneration
- Author
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Hongbo Yu, Qingcheng Liu, Gaozhi Jia, Yu Zhuang, Hongliang Li, and Guangyin Yuan
- Subjects
Calcium Phosphates ,Scaffold ,Materials science ,Bone Regeneration ,Biocompatibility ,0206 medical engineering ,Biomedical Engineering ,02 engineering and technology ,engineering.material ,Biomaterials ,Coating ,In vivo ,Biomimetics ,Osteogenesis ,Alloys ,Animals ,Brushite ,Bone regeneration ,Regeneration (biology) ,technology, industry, and agriculture ,equipment and supplies ,021001 nanoscience & nanotechnology ,020601 biomedical engineering ,Zinc ,engineering ,Surface modification ,Rabbits ,0210 nano-technology ,Biomedical engineering - Abstract
Bone tissue engineering is considered as a promising pathway for bone regeneration and defect reconstruction, in which scaffolds play an important role. Zn alloy, which is a biodegradable metal material that has advantages of metallic and biodegradable characteristics, has its special features, especially the ideal degradation rate and acceptable biocompatibility, which make it worthy to be further investigated for medical applications. In this study, new biodegradable porous Zn alloy scaffolds with Ca-P coating were attempted to repair cranial bone defect, and in vitro and in vivo assays were conducted to evaluate its biocompatibility, osteo-inductivity, and osteo-conductivity. The results indicated that coated Zn alloy possessed good biocompatibility, with no cytotoxicity. It could also promote osteogenic differentiation and calcium deposition of rabbit BMSCs in vitro, and new bone formation around the scaffold in vivo. The biodegradable porous Zn alloy scaffold with Ca-P coating is considered to be promising in cranial bone defect repair.
- Published
- 2021