1. Novel Positron Emission Tomography Radiotracers for Imaging Mitochondrial Complex I
- Author
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Can Zhang, Shijun Zhang, Ping Bai, Yan Liu, Yiming Xu, Savannah Biby, Changning Wang, and Yulong Xu
- Subjects
Cerebellum ,Fluorine Radioisotopes ,Physiology ,Cognitive Neuroscience ,Central nervous system ,Biochemistry ,Article ,Midbrain ,Positron Emission Tomography Computed Tomography ,medicine ,Inner membrane ,chemistry.chemical_classification ,Reactive oxygen species ,Electron Transport Complex I ,medicine.diagnostic_test ,Chemistry ,Brain ,Cell Biology ,General Medicine ,Electron transport chain ,medicine.anatomical_structure ,Positron emission tomography ,Positron-Emission Tomography ,Biophysics ,Radiopharmaceuticals ,Mitochondrial Complex I - Abstract
Mitochondrial dysfunction has been indicated in neurodegenerative and other disorders. The mitochondrial complex I (MC-I) of the electron transport chain (ETC) on the inner membrane is the electron entry point of the ETC and is essential for the production of reactive oxygen species. Based on a recently identified β-keto-amide type MC-I modulator from our laboratory, an (18)F-labeled positron emission tomography (PET) tracer, (18)F-2, was prepared. PET/CT imaging studies demonstrated that (18)F-2 exhibited rapid brain uptake without significant wash out during the 60 min scanning time. In addition, the binding of (18)F-2 was higher in the regions of the brain stem, cerebellum, and midbrain. The uptake of (18)F-2 can be significantly blocked by its parent compound. Collectively, the results strongly suggest successful development of MC-I PET tracers from this chemical scaffold that can be used in future mitochondrial dysfunction studies of the central nervous system.
- Published
- 2021