1. Targeting TSPO Reduces Inflammation and Apoptosis in an In Vitro Photoreceptor-Like Model of Retinal Degeneration
- Author
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Francesca Corsi, Emma Baglini, Elisabetta Barresi, Silvia Salerno, Chiara Cerri, Claudia Martini, Federico Da Settimo Passetti, Sabrina Taliani, Claudia Gargini, and Ilaria Piano
- Subjects
Lipopolysaccharides ,Inflammation ,Physiology ,Cognitive Neuroscience ,Retinal Degeneration ,Neurodegenerative Diseases ,Apoptosis ,Cell Biology ,General Medicine ,Ligands ,Biochemistry ,Receptors, GABA ,Humans ,Carrier Proteins - Abstract
The 18 kDa translocator protein (TSPO) is predominantly located in the mitochondrial outer membrane, playing an important role in steroidogenesis, inflammation, survival, and cell proliferation. Its expression in the CNS, and mainly in glial cells, is upregulated in neuropathologies and brain injury. In this study, the potential of targeting TSPO for the therapeutic treatment of inflammatory-based retinal neurodegeneration was evaluated by means of an in vitro model of lipopolysaccharide (LPS)-induced degeneration in 661 W cells, a photoreceptor-like cell line. After the assessment of the expression of TSPO in 661W cells, which, to the best of our knowledge, was never investigated so far, the anti-inflammatory and cytoprotective effects of a number of known TSPO ligands, belonging to the class of
- Published
- 2022
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