1. Coevolution of Atomic Resolution and Whole-Brain Imaging for Tau Neurofibrillary Tangles
- Author
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Raeann M Dalton, Victoria S Parker, Jacob M. Hooker, Hema S. Krishnan, and Mary C. Catanese
- Subjects
Physiology ,Cognitive Neuroscience ,Neuroimaging ,tau Proteins ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,Atomic resolution ,Alzheimer Disease ,medicine ,Technique development ,Humans ,Clinical imaging ,030304 developmental biology ,Physics ,0303 health sciences ,medicine.diagnostic_test ,Brain ,Neurofibrillary tangle ,Neurofibrillary Tangles ,Cell Biology ,General Medicine ,medicine.disease ,Positron emission tomography ,Positron-Emission Tomography ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Neurofibrillary tangle (NFT) imaging methods at the distinct scales of atomic and whole-brain resolutions have coevolved rapidly. Linking these two areas of research provides insight into how and why certain tau radiotracers, using positron emission tomography (PET), bind selectively to certain morphological forms of the NFT fibril. In this Review, a brief history and background for each research area is presented leading to a summary of the current state of knowledge, with a synopsis of PET NFT radiotracers and an outlook for near-term research efforts. The continued integration of information provided at the level of each of these scales of resolution will catalyze the next generation of clinical imaging technique development and enhance our interpretations of them.
- Published
- 2020