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Start Over Author "Hye Ri, Lee" Journal acs combinatorial science
2 results on '"Hye Ri, Lee"'

1. Efficient, Solvent-Free, Multicomponent Method for Organic-Base-Catalyzed Synthesis of β-Phosphonomalonates

Author

Hongsuk Suh, Huiju Park, Reddi Mohan Naidu Kalla, Hye Ri Lee, and Il Kim

Subjects
Aldehydes, Solvent free, Combinatorial Chemistry Techniques, Organic base, Molecular Structure, Chemistry, Organophosphonates, General Chemistry, General Medicine, Butylamines, Catalysis, Organophosphorus Compounds, Nitriles, Molecule, Organic chemistry
Abstract

An efficient, one-pot, di-n-butylamine-catalyzed, three-component synthesis of β-phosphonomalonates has been developed. A wide range of substrates, including aromatic and fused aromatic aldehydes, were condensed with enolizable C–H activated compounds and dialkylphosphites to give the desired products in excellent yields. This method provides an eco-friendly alternative approach to rapid construction of a diversity-oriented library of β-phosphonomalonates.

Published
2015

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