Search

Your search keyword '"Karl Richard Gibson"' showing total 1 results
Start Over Author "Karl Richard Gibson" Journal acs medicinal chemistry letters
1 results on '"Karl Richard Gibson"'

1. Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain

Author

Mark L. Lewis, Charlotte Alice Louise Lane, Blanda Luzia Christa Stammen, David James Rawson, Peter J. Bungay, William A. Million, Stephen Martin Denton, Sharan K. Bagal, Tanya L. Hay, C. Elizabeth Payne, Lisa R. Thompson, Maw Graham Nigel, Cedric Poinsard, Karl Richard Gibson, Kemp Mark Ian, Edward B. Stevens, and Melanie S. Glossop

Subjects
business.industry, Sodium channel, Organic Chemistry, Drug Discovery, NAV1, Medicine, Pharmacology, Subtype selective, business, Inflammatory pain, Biochemistry
Abstract

Voltage-gated sodium channels, in particular Nav1.8, can be targeted for the treatment of neuropathic and inflammatory pain. Herein, we described the optimization of Nav1.8 modulator series to deliver subtype selective, state, and use-dependent chemical matter that is efficacious in preclinical models of neuropathic and inflammatory pain.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results