1. Catalytic Nanoassemblies Formed by Short Peptides Promote Highly Enantioselective Transfer Hydrogenation.
- Author
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Dolan MA, Basa PN, Zozulia O, Lengyel Z, Lebl R, Kohn EM, Bhattacharya S, and Korendovych IV
- Subjects
- Amino Acids chemistry, Hydrogenation drug effects, Ketones chemistry, Molecular Structure, Nanostructures classification, Ruthenium chemistry, Stereoisomerism, Catalysis, Nanostructures chemistry, Peptides chemistry, Water chemistry
- Abstract
Self-assembly enables formation of incredibly diverse supramolecular structures with practically important functions from simple and inexpensive building blocks. Here, we show how a semirational, bottom-up approach to create emerging properties can be extended to a design of highly enantioselective catalytic nanoassemblies. The designed peptides comprising as few as two amino acid residues spontaneously self-assemble in the presence of metal ions to form supramolecular, vesicle-like nanoassemblies that promote transfer hydrogenation of ketones in an aqueous phase with excellent conversion rates and enantioselectivities (>90% ee).
- Published
- 2019
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