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Start Over Author "Hong, Seungpyo" Journal acs nano
5 results on '"Hong, Seungpyo"'

4. Synthesis, Characterization, and in Vitro Testing of Superparamagnetic Iron Oxide Nanoparticles Targeted Using Folic Acid-Conjugated Dendrimers

Author

Landmark, Kevin J., primary, DiMaggio, Stassi, additional, Ward, Jesse, additional, Kelly, Christopher, additional, Vogt, Stefan, additional, Hong, Seungpyo, additional, Kotlyar, Alina, additional, Myc, Andrzej, additional, Thomas, Thommey P., additional, Penner-Hahn, James E., additional, Baker, James R., additional, Holl, Mark M. Banaszak, additional, and Orr, Bradford G., additional

Published
2008
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5. Synthesis, Characterization, and in VitroTesting of Superparamagnetic Iron Oxide Nanoparticles Targeted Using Folic Acid-Conjugated Dendrimers

Author

J. Landmark, Kevin, Kelly, Christopher, Hong, Seungpyo, Kotlyar, Alina, Myc, Andrzej, P. Thomas, Thommey, R. Baker Jr., James, M. Banaszak Holl, Mark, G. Orr, Bradford, J. Landmark, Kevin, Kelly, Christopher, M. Banaszak Holl, Mark, G. Orr, Bradford, DiMaggio, Stassi, Ward, Jesse, E. Penner-Hahn, James, M. Banaszak Holl, Mark, Kelly, Christopher, M. Banaszak Holl, Mark, Kelly, Christopher, E. Penner-Hahn, James, M. Banaszak Holl, Mark, Vogt, Stefan, Hong, Seungpyo, M. Banaszak Holl, Mark, and G. Orr, Bradford

Abstract

Organic-coated superparamagnetic iron oxide nanoparticles (OC-SPIONs) were synthesized and characterized by transmission electron microscopy and X-ray photoelectron spectroscopy. OC-SPIONs were transferred from organic media into water using poly(amidoamine) dendrimers modified with 6-TAMRA fluorescent dye and folic acid molecules. The saturation magnetization of the resulting dendrimer-coated SPIONs (DC-SPIONs) was determined, using a superconducting quantum interference device, to be 60 emu/g Fe versus 90 emu/g Fe for bulk magnetite. Selective targeting of the DC-SPIONs to KB cancer cells in vitro was demonstrated and quantified using two distinct and complementary imaging modalities: UV–visible and X-ray fluorescence; confocal microscopy confirmed internalization. The results were consistent between the uptake distribution quantified by flow cytometry using 6-TAMRA UV–visible fluorescence intensity and the cellular iron content determined using X-ray fluorescence microscopy.

Published
2008
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