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Your search keyword '"Xu, Xiaoxia"' showing total 5 results
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5 results on '"Xu, Xiaoxia"'

3. Ultrasound-Activatable In SituVaccine for Enhanced Antigen Self- and Cross-Presentation to Overcome Cancer Immunotherapy Resistance

Author

Chen, Ge, Wang, Yongchao, Mo, Lianfeng, Xu, Xiaoxia, Zhang, Xu, Yang, Siyi, Huang, Rong, Li, Ruifang, Zhang, Lianzhong, and Zhang, Beibei

Abstract

Insufficient antigen self-presentation of tumor cells and ineffective antigen cross-presentation by dendritic cells (DCs) contribute to diminished immune recognition and activation, which cause resistance to immunotherapies. Herein, we present an ultrasound-activatable in situvaccine by utilizing a hybrid nanovesicle composed of a thylakoid (TK)/platelet (PLT) membrane and a liposome encapsulating DNA methyltransferase inhibitor zebularine (Zeb) and sonosensitizer hematoporphyrin monomethyl ether (HMME). Upon local exposure to ultrasound, reactive oxygen species (ROS) are generated and induce the sequential release of the payloads. Zeb can efficiently inhibit tumor DNA hypermethylation, promoting major histocompatibility complex class I (MHC-I) molecules-mediated antigen self-presentation to improve immune recognition. Meanwhile, the catalase on the TK membrane can decompose the tumoral overexpressed H2O2into O2, which boosts the generation of ROS and the destruction of tumor cells, resulting in the in situantigen release and cross-presentation of tumor antigens by DCs. This in situvaccine simultaneously promotes antigen self-presentation and cross-presentation, resulting in heightened antitumor immunity to overcome resistance.

Published
2024
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5. ZnO-based hollow nanoparticles by selective etching: elimination and reconstruction of metal-semiconductor interface, improvement of blue emission and photocatalysis.

Author

Zeng H, Cai W, Liu P, Xu X, Zhou H, Klingshirn C, and Kalt H

Subjects
Catalysis, Color, Macromolecular Substances chemistry, Materials Testing, Metals chemistry, Molecular Conformation, Particle Size, Photochemistry methods, Semiconductors, Surface Properties, Crystallization methods, Lighting methods, Nanostructures chemistry, Nanostructures ultrastructure, Nanotechnology methods, Zinc Oxide chemistry
Abstract

A weak acid selective etching strategy was put forward to fabricate oxide-based hollow nanoparticles (HNPs) using core/shell nanostructures of active metal/oxide nanoparticles as sacrificial templates. ZnO-based HNPs, including pure ZnO, Au/ZnO, Pt/ZnO, and Au/Pt/ZnO HNPs with diameter below 50 nm and shell thickness below 6 nm has been first achieved at low temperature. The diameter, thickness, and even sizes of ZnO and noble metal ultrafine crystals of HNPs can be well adjusted by the etching process. Synchronous with the formation of HNPs, the internal metal-semiconductor interfaces can be controllably eliminated (Zn-ZnO) and reconstructed (noble metal-ZnO). Excitingly, such microstructure manipulation has endued them with giant improvements in related performances, including the very strong blue luminescence with enhancement over 3 orders of magnitude for the pure ZnO HNPs and the greatly improved photocatalytic activity for the noble metal/ZnO HNPs. These give them strong potentials in relevant applications, such as blue light emitting devices, environment remediation, drug delivery and release, energy storage and conversion, and sensors. The designed fabrication procedure is simple, feasible, and universal for a series of oxide and noble metal/oxide HNPs with controlled microstructure and improved performances.

Published
2008
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