1. Concentration- and time-dependent effect of aminooxyacetic acid on cortical epileptogenicity
- Author
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László Vécsei, Barbara Barna, Zoltán Szupera, András Szász, T. Asztalos, Helmi Houtzager, and Magdolna Szente
- Subjects
Male ,medicine.medical_specialty ,In Vitro Techniques ,General Biochemistry, Genetics and Molecular Biology ,chemistry.chemical_compound ,Internal medicine ,medicine ,Extracellular ,Animals ,Rats, Wistar ,Evoked Potentials ,Volume concentration ,General Environmental Science ,Epilepsy ,Dose-Response Relationship, Drug ,Chemistry ,Aminooxyacetic Acid ,Aminooxyacetic acid ,Rats ,Electrophysiology ,Endocrinology ,nervous system ,Neurology ,Excitatory postsynaptic potential ,NMDA receptor ,Female ,Cortical inhibition ,Neuroscience - Abstract
In the present electrophysiological study the effect of aminooxyacetic acid (AOAA) on the cortical epileptogenicity, and on the basic electro-cortical activity was investigated in anesthetized rats. AOAA did not induce spontaneous epileptiform discharges but modified the somato-sensory evoked responses and the cortical epileptogenicity (induced by 4-aminopyridine) in the same manner depending on its concentration. AOAA at low concentrations increased the amplitude of evoked responses and the ipsilateral manifestation of epileptiform activity, however, at high concentrations significantly suppressed both the evoked responses and the induction and expression of seizures discharges. The anticonvulsive effect of AOAA was time-dependent (reached its maximum after 2h AOAA pre-treatment) and reversible. AOAA at low concentrations probably increases the efficacy of the NMDA excitatory system and decreases GABA-synthesis, resulting neuronal hyperexcitation. However, AOAA at high concentrations can lead to an effective cortical inhibition through intra- and extracellular accumulation of GABA. The gradual GABA accumulation - up to a certain level - at the synapses could also explain the time-dependency of the anticonvulsive effect of AOAA.
- Published
- 2002