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Your search keyword '"Shuya Feng"' showing total 1 results
Start Over Author "Shuya Feng" Journal acta biomaterialia
1 results on '"Shuya Feng"'

1. Lipase-triggered drug release from BCL2 inhibitor ABT-199-loaded nanoparticles to elevate anti-leukemic activity through enhanced drug targeting on the mitochondrial membrane

Author

Bin, Liang, Dawei, Jiang, Luqi, Pan, Fang, Xiong, Shuya, Feng, Shenghao, Wu, Haige, Ye, Zhijie, Yu, Changcan, Shi, and Shenmeng, Gao

Subjects
Sulfonamides, Polymers, Biomedical Engineering, Antineoplastic Agents, Apoptosis, Lipase, General Medicine, Bridged Bicyclo Compounds, Heterocyclic, Biochemistry, Biomaterials, Drug Liberation, Leukemia, Myeloid, Acute, Mice, Drug Delivery Systems, Proto-Oncogene Proteins c-bcl-2, Cell Line, Tumor, Mitochondrial Membranes, Animals, Humans, Nanoparticles, Molecular Biology, Biotechnology
Abstract

Selective BCL2 inhibitor ABT-199 has been approved to treat hematological malignancies including acute myeloid leukemia (AML). However, acquired drug resistance and severe side effects occur after extended treatment limiting the clinical usage of ABT-199. Here, we successfully encapsulated pure ABT-199 in amphiphilic mPEG-b-PTMC

Published
2022
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