1. Three trifluoromethyl-substituted protoporphyrinogen IX oxidase inhibitors.
- Author
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Bin Lu, Yu-Ming Lan, Chu-Tung Hsu, Zhen-Long Liu, Hai-Bin Song, Chao Wu, and Hua-Zheng Yang
- Subjects
ORGANIC compounds ,MOLECULAR structure ,BENZENE ,PIPERIDINE ,CHEMISTRY ,CRYSTALLOGRAPHY - Abstract
The structures of methyl 5-[2-chloro-4-(trifluoromethyl)Phenoxy]-2-nitrobenzoate, C
15 H9 ClF3 N3 O5 , (I), methyl 2-chloro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydro-pyrimidin-1-y1]benzoate, C14 H10 ClF3 N2 O4 , (II), and 2-[4-chloro-2-fluoro-5(prop-2-ynyloxy)phenyl]-4-(trifluoromethyl)piperidine-2.6-dione, C15 H10 ClF4 NO3 , (III), are similar in their dihedral angles and in the distances between the farthest two atoms. There are two independent molecules in the structure of (I). The dihedral angles between the two aromatic rings in each molecule in (I), between the benzene and tetrahydropyrimidine rings in (II), and between the benzene ring and the five-atom planar portion of the piperidine-2,6-dione ring in (III) are 80.78 (11)189.75 (11), 89.13 (9) and 87.52 (13)°, respectively. The distances between the farthest two atoms, viz. O···F in the two molecules of (I), and Cl···F in (II) and (III), are 11.763 (7)111.953 (6), 10.734 (10) and 10.889 (9) Å, respectively. In all three crystal structures, the molecules are linked to generate sheets of molecules via C—H···O interactions. [ABSTRACT FROM AUTHOR]- Published
- 2005
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