1. Beclomethasone dipropionate crystallized from HFA-134a and ethanol
- Author
-
Paul B. Myrdal, Michael D. Carducci, and Julie A. Harris
- Subjects
Solvent ,chemistry.chemical_compound ,Ethanol ,chemistry ,Inhalation ,Hydrogen bond ,Hfa 134a ,General Materials Science ,General Chemistry ,Crystal structure ,respiratory system ,Condensed Matter Physics ,Nuclear chemistry - Abstract
Beclomethasone dipropionate (BDP) is a long-acting inhaled corticosteroid, used for the treatment of asthma, and as an inhalation therapy with HFA-134a. The sample studied by X-ray crystallography was grown in a mixture of the aerosol propellant HFA-134a, C2H2F4, and 200-proof ethanol. The formula of the crystalline material is C28H37ClO7·2C2H6O·C2H2F4. In the crystal structure, disordered solvent occupies a channel which is perpendicular to the BDP molecules. The latter are are stacked together by hydrogen bonding.
- Published
- 2003