1. Lymphonodular Cryptococcosis Diagnosed by Fine Needle Aspiration Cytology in Hyper-IgM Syndrome
- Author
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Chang Soo Park, Sang-Woo Juhng, Chan Choi, Jae-Hun Chung, Jong-Hee Nam, Tai-Ju Hwang, Min Young Lee, Jae Hyuk Lee, Min-Cheol Lee, Kyung-Soo Kim, and Jong-Hee Shin
- Subjects
Pathology ,medicine.medical_specialty ,Hyper IgM syndrome ,Histology ,medicine.diagnostic_test ,business.industry ,General Medicine ,medicine.disease ,Pathology and Forensic Medicine ,medicine.anatomical_structure ,Cytopathology ,Cervical lymph nodes ,Biopsy ,Cryptococcosis ,medicine ,business ,Lymph node ,Meningitis ,Mycosis - Abstract
Background Most cases of cryptococcosis are diagnosed when signs of meningitis have appeared. We report a case of lymphonodular cryptococcosis that was diagnosed by fine needle aspiration cytology (FNAC), excisional biopsy of a cervical lymph node and culture of aspirated material. Case An 11-year-old boy presented with a history of fever and enlarged bilateral cervical lymph nodes of two weeks' duration. Past medical history included immunoglobulin replacement for hyper-IgM syndrome for the previous eight years. FNAC smears from a cervical lymph node showed numerous yeasts of various sizes, ranging from 5 to 15 microns in diameter, located in the cytoplasm of multinucleated giant cells and in the background. In air-dried, Diff-Quik-stained slides, the yeasts stained blue and were surrounded by clear halos. Aspirated material collected in the syringe was cultured, and Cryptococcus neoformans was isolated. Conclusion This case report suggests that a combination of FNAC and culture is a simple and useful method of diagnosing fungal infections. Early diagnosis by FNAC makes possible the early initiation of treatment.
- Published
- 2001
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