1. Efficacy and transdermal absorption of permethrin in scabies patients.
- Author
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van der Rhee HJ, Farquhar JA, and Vermeulen NP
- Subjects
- Adult, Female, Humans, Male, Ointments, Permethrin, Pyrethrins administration & dosage, Pyrethrins adverse effects, Scabies pathology, Pyrethrins pharmacokinetics, Scabies metabolism, Skin Absorption
- Abstract
The clinical efficacy and transdermal absorption of permethrin, a new synthetic insecticide was investigated in ten scabies patients. All patients were successfully treated with one application of a cream, containing 5% permethrin. Apart from mild postscabies dermatitis no side-effects were observed. The mean weight of cream used per patient was 25 g (range 21-32; mean content of permethrin 1250 mg). The degree of permethrin absorption was assessed indirectly by determination of conjugated and unconjugated cis- and trans-CVA (a metabolite of permethrin) excretion in urine using two dimensional gas chromatography mass spectrometry. It was found that during the first 48 hours the mean estimated absorption was 6 mg (range 3-11), which is approximately 0.5% of the total dose.
- Published
- 1989