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We investigated the expression of both epidermal fatty acid-binding protein (FABP5), a marker of transit amplifying cells, and nestin, a putative marker of epidermal stem cells, in psoriatic epidermis and in normal human cultured keratinocytes. In lesional psoriatic epidermis, immunostaining showed that the suprabasal layer was positive for nestin, with some cells co-expressing FABP5. Flow cytometric analysis revealed that the expression of both nestin and FABP5 were increased in keratinocytes cultured in a low concentration of calcium relative to those cultured in a high concentration of calcium. These results suggest that nestin and FABP5 are expressed in actively proliferating keratinocytes in vitro and in the suprabasal layer in lesional psoriatic epidermis, and that double-positive cells may identify transit amplifying cells in the epidermis. [ABSTRACT FROM AUTHOR]

The article presents a case study of a 71-year-old man having pigmented macules of one month duration. Microscopic examination revealed sheets of cells abundant eosinophilic cytoplasm, enlarged nuclei and several mitotic figures. Immunohistochemical studies were negative for CD56, CD20, CD8, CD4 and CD3, and positive for lysozyme, myeolo-peroxidase, CD45 and CD43, which confirms myeloid sarcoma diagnosis.

The article presents a case study of a 70-year-old Japanese man who suffered erythema on his knee and forearm after the sorafenib treatment for stage IV renal cell carcinoma. The patient died from renal cell carcinoma before performing various tests. The article discusses about sorafenib and its effects to the metastatic renal cell cancer patients including hand-foot skin reactions, alopecia and stomatitis.