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Linear IgA/IgG bullous dermatosis (LAGBD) is an autoimmune blistering disease characterized by the local accumulation of IgA- and IgG-class anti-basement membrane autoantibodies. It typically presents as a generalized pruritic vesiculobullous eruption. No cases of localized LAGBD have yet been reported. We report a case of a 78-year-old man with LAGBD localized to the perianal area. The patient complained of suffering from persistent ulcers around the anus for more than 3 years. Physical examination revealed several blisters and ulcers up to 2-cm in diameter around the anus. No lesions were found elsewhere on the body. Histological analysis of a skin biopsy revealed subepidermal blistering, while direct immunofluorescence showed the linear deposition of IgA and IgG antibodies at the dermoepidermal junction. Indirect immunofluorescence of normal human skin whose layers had been separated using 1M NaCl showed the binding of both IgA and IgG to the epidermal side. Immunoblotting demonstrated the presence of circulating IgA and IgG autoantibodies that bound to a 120-kDa protein. This is the first case of localized LAGBD whose skin lesions were restricted to the perianal region. [ABSTRACT FROM AUTHOR]

The article describes cases of older patients with methotrexate-associated lymphoproliferative disorders (MTX-LPD). Topics cited include the cutaneous manifestations of MTX-LPD, association of MTX with Epstein-Barr virus (EBV) positive diffuse large B-cell lymphoma, spontaneous regression of lymphoma after MTX discontinuation, and expression of EBV in tumor cells.

A case study describing the exacerbation of pemphigus foliaceus after electron-beam radiation for extramammary Paget's disease is presented. Topics discussed include the clinical history of the patient, how the diagnosis of pemphigus foliaceus was made, and the necessity of precautions against the exacerbation of pemphigus after irradiation. The need to be aware of the occurrence of pemphigus after irradiation even in cases with no history of blistering diseases is noted.

The article describes a case study concerning a 31-year-old male patient with Kindler syndrome (KS) accompanied by severe intestinal involvement. Topics discussed include multiple blisters and erosions presented by the patient at birth, mutations in the FERMT1 gene that cause KS, and cutaneous features. Also mentioned are intestinal involvement such as colitis and diarrhea in childhood, occurrence of severe late-onset ileal strictures, and genotype correlation.

The article describes a case study concerning a 63-year-old man diagnosed with myelodysplastic syndrome (MDS) and acquired trisomy 8. Topics discussed include the development of oral aphthae, intestinal and genital ulceration and high fever, the symptoms' similarity to those of Behçet's disease (BD), and gene expression patterns. Also mentioned are screening for underlying hematological disorders and better training of dermatologists to examine patients with BD-like mucocutaneous lesions.