1. Probable acenocoumarol-amoxycillin interaction.
- Author
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Soto J, Sacristan JA, Alsar MJ, Fernandez-Viadero C, and Verduga R
- Subjects
- Acenocoumarol administration & dosage, Aged, Aged, 80 and over, Drug Interactions, Drug Therapy, Combination, Female, Humans, Postoperative Complications blood, Postoperative Complications drug therapy, Respiratory Tract Infections blood, Respiratory Tract Infections drug therapy, Thrombophlebitis blood, Thrombophlebitis drug therapy, Time Factors, Acenocoumarol adverse effects, Amoxicillin adverse effects
- Abstract
We present the case of a woman undergoing treatment with acenocoumarol for deep vein thrombosis, who maintained an international normalized ratio (INR) of between 2.5 and 4 for 2 months. Seven days after the introduction of amoxycillin (500 mg/8 h) for a probable respiratory infection, the patient developed spontaneous bruising, with an INR of 7.1. Treatment with amoxycillin was discontinued, and 3 weeks later the INR had returned to previous values. In this case, the increase in the INR value with associated bruising after the addition of amoxycillin suggests a drug interaction between acenocoumarol and amoxycillin, other possible causes having been eliminated.
- Published
- 1993
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