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In this paper, we introduce the concept of second-order compound contingent epiderivative for set-valued maps and discuss its relationship to the second-order contingent epiderivative. Simultaneously, we also investigate some special properties of the second-order compound contingent epiderivative. By virtue of the second-order compound contingent epiderivative, we establish some unified second-order sufficient and necessary optimality conditions for set-valued optimization problems. All results in this paper generalize the corresponding results in the literature. [ABSTRACT FROM AUTHOR]