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Your search keyword '"Vojtěch Adam"' showing total 2 results
Start Over Author "Vojtěch Adam" Journal acta medica
2 results on '"Vojtěch Adam"'

1. Melatonin Regulates Oxidative Stress Initiated by Freund’s Complete Adjuvant

Author

Miroslav Pohanka, Branislav Ruttkay-Nedecký, Josef Fusek, Vojtěch Adam, and René Kizek

Subjects
Antioxidant, Oxidative stress, Melatonin, Reactive oxygen species, Epiphysis, Hormone, Medicine
Abstract

Melatonin is a hormone with strong antioxidant properties. In this experiment, Freund’s complete adjuvant was used as a stressogenic substance given to laboratory outbred mice, whereas melatonin was investigated as a protectant against the stressogenic effect. Levels of low molecular weight antioxidants, thiobarbituric acid reactive substances, and tumor necrosis factor α and activity of glutathione reductase were determined in blood from the animals. Surprisingly, melatonin was not involved in direct regulation of antioxidants, thiobarbituric acid reactive substances and tumor necrosis factor α. On the other hand, melatonin regulated glutathione reductase activity. We can conclude on regulation of metabolism caused by melatonin in the model. The effect was more important than the expected regulation of immunity and basal oxidative homeostasis.

Published
2015
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2. Melatonin Regulates Oxidative Stress Initiated by Freund’s Complete Adjuvant

Author

Josef Fusek, Branislav Ruttkay-Nedecký, Miroslav Pohanka, Vojtěch Adam, and René Kizek

Subjects
medicine.medical_specialty, Antioxidant, Thiobarbituric acid, medicine.medical_treatment, Glutathione reductase, Freund's Adjuvant, lcsh:Medicine, Biology, medicine.disease_cause, Antioxidants, Melatonin, chemistry.chemical_compound, Mice, Adjuvants, Immunologic, Internal medicine, medicine, Animals, chemistry.chemical_classification, Reactive oxygen species, Dose-Response Relationship, Drug, lcsh:R, General Medicine, Hormone, Endocrinology, chemistry, Freund's adjuvant, Oxidative stress, Tumor necrosis factor alpha, Female, Epiphysis, hormones, hormone substitutes, and hormone antagonists, medicine.drug
Abstract

Melatonin is a hormone with strong antioxidant properties. In this experiment, Freund’s complete adjuvant was used as a stressogenic substance given to laboratory outbred mice, whereas melatonin was investigated as a protectant against the stressogenic effect. Levels of low molecular weight antioxidants, thiobarbituric acid reactive substances, and tumor necrosis factor α and activity of glutathione reductase were determined in blood from the animals. Surprisingly, melatonin was not involved in direct regulation of antioxidants, thiobarbituric acid reactive substances and tumor necrosis factor α. On the other hand, melatonin regulated glutathione reductase activity. We can conclude on regulation of metabolism caused by melatonin in the model. The effect was more important than the expected regulation of immunity and basal oxidative homeostasis.

Published
2015

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