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Background: Chromophobe Renal Cell Carcinoma is the 3rd most common subtype of RCC. It is most frequently sporadic however, several familial cases, associated with Birt-Hogg Dubé syndrome, have been described. Material and Methods: A 68 year-old male which on CT examination, presents in the left hepatic lobe a focal lesion of 93 mm, well delimited with contrast socket. Liver biopsy is performed. Microscopic examination shows a tumor proliferation with a pseudoglandular- pseudo-accinar pattern with the delimitation of numerous vascular spaces. Immunohistochemical tumor cells are positive for CTK7 and CTK8 / 18 and negative for CEA, CTK19, CTK20 and CDX2 immunolabeling. Based on the immunohistochemical profile and morphological aspect, the diagnosis was malignant hepatic tumor possible hepatocellular carcinoma but a gastric metastasis of a carcinom with hepatoid pattern cannot be excluded. One week later it was found that the patient had a history of renal tumor, whose histopathological diagnosis was of chromophobe renal cell carcinoma. The immunohistochemical panel was supplemented with the reaction to CD117 in which the tumor cells were diffused positive and thus the definitive diagnosis of hepatic metastasis of renal carcinoma with chromophobic cells was established. Conclusion: In order to establish the primary origin of a liver metastasis, all the clinical information and all the pathological history of the patient are required. [ABSTRACT FROM AUTHOR]