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Your search keyword '"Arakawa, Kyosuke"' showing total 2 results
Start Over Author "Arakawa, Kyosuke" Journal acta medica okayama
2 results on '"Arakawa, Kyosuke"'

1. Quercetin Attenuates Neuropathic Pain in Rats with Spared Nerve Injury

Author

Muto, Noriko, Matsuoka, Yoshikazu, Arakawa, Kyosuke, Kurita, Masako, Omiya, Hiroki, Taniguchi, Arata, Kaku, Ryuji, and Morimatsu, Hiroshi

Subjects
Male, dorsal root ganglion, alternative medicine, Rats, Rats, Sprague-Dawley, nervous system, Ganglia, Spinal, Glial Fibrillary Acidic Protein, Animals, Neuralgia, heterocyclic compounds, flavonoid, Quercetin, Neuroglia, Cells, Cultured
Abstract

Quercetin is a flavonoid widely found in plants and marketed to the public as a supplement. Several studies have reported its effect on glial cells. This study aimed to examine the effect of quercetin on the development of neuropathic pain and the underlying mechanism in a spared nerve injury (SNI) rat model. Male Sprague-Dawley rats randomly assigned to the control or the quercetin group were subjected to SNI of the sciatic nerve. We measured pain behaviors on the hind paw and glial fibrillary acidic protein (GFAP) in the dorsal root ganglion (DRG) and spinal cord. Oral administration of 1% quercetin, begun before surgery, attenuated mechanical allodynia compared to the control group at days 7 and 10 after SNI. On the other hand, established pain was not attenuated in a post-dose group in which quercetin was begun 7 days after SNI. Quercetin inhibited GFAP in the satellite glial cells of the ipsilateral L5 DRG on day 7 compared to the control group. Quercetin suppressed the development of neuropathic pain through a mechanism partly involving the inhibition of satellite glial cells. As its safety is well established, quercetin has great potential for clinical use in pain treatment.

Published
2018

2. A Multidisciplinary Approach to the Management of Chronic Pain through a Self-managed Behavioral Exercise Program : A Pilot Study in Japan.

Author

Nishie H, Tetsunaga T, Kanzaki H, Oda K, Inoue S, Ryuo Y, Ota H, Miyawaki T, Arakawa K, Tetsunaga T, Kitamura Y, Sendo T, Morimatsu H, Ozaki T, and Nishida K

Subjects
Chronic Pain psychology, Humans, Pain Measurement, Pilot Projects, Quality of Life, Chronic Pain therapy, Exercise Therapy, Pain Management methods, Patient Care Team, Self-Management
Abstract

We conducted this study to determine the short-term treatment outcomes of multidisciplinary approaches to chronic pain management for outpatients in Japan. We evaluated pain reduction and improvement in quality of life (QOL) after treatment. We analyzed 32 patients who had experienced intractable chronic pain for > 3 months. The patients received multidisciplinary therapeutic self-managed exercise instructions and then underwent evaluations 1 and 3 months after the treatment. We used the Pain Disability Short Form-36 (SF-36), Pain Catastrophizing Scale (PCS), and Pain Disability Assessment Scale (PDAS) to evaluate QOL. Although the pain levels were the same before and after the physical exercise program, the patients showed significant improvements in physical function on the SF-36 (48.5 vs. 54.5, 3 months vs. 1 month; p=0.0124), the magnification subscale on the PCS (6.8 vs. 5.9, 1 month vs. before; p=0.0164) and the PDAS (29.2 vs. 23.4, 3 months vs. before; p=0.0055). Chronic pain should be treated with a biopsychosocial approach, but time constraints and costs have limited the implementation of multidisciplinary and behavioral approaches to chronic pain management. Our findings demonstrate that clinical improvements are possible for patients with chronic pain, using multidisciplinary team resources widely available in Japanese clinical practice., Competing Interests: No potential conflict of interest relevant to this article was reported.

Published
2018
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