1. Risco cardiometabólico na infância : pode a bilirrubina atuar como mediador associado ao relógio circadiano via disfunção autonómica?
- Author
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Meira e Cruz, Miguel, Rocha, Isabel, Bruni, Oliviero, and Repositório da Universidade de Lisboa
- Subjects
Physiology ,Maternal Health ,Circadian clock ,lcsh:Medicine ,Blood Pressure ,Cardiovascular Medicine ,Bioinformatics ,Vascular Medicine ,Families ,chemistry.chemical_compound ,Pregnancy ,Medicine and Health Sciences ,Bile ,Medicine ,Children ,Cardiometabolic risk ,child ,lcsh:R5-920 ,Obstetrics and Gynecology ,Hematology ,General Medicine ,Clinical Laboratory Sciences ,Body Fluids ,Cardiovascular Diseases ,Anatomy ,bilirubin ,lcsh:Medicine (General) ,Infants ,Research Article ,circadian rhythm ,hypertension ,Bilirubin ,Autonomic Nervous System ,Child ,Circadian Rhythm ,Hypertension ,Humans ,Infant, Newborn ,Autonomic Nervous System Diseases ,Circadian Clocks ,Mediator ,Hypertensive Disorders in Pregnancy ,Diagnostic Medicine ,Blood Transfusion ,Circadian rhythm ,Transfusion Medicine ,business.industry ,autonomic nervous system ,lcsh:R ,Biology and Life Sciences ,Neonates ,Infant ,Newborn ,Autonomic nervous system ,chemistry ,Age Groups ,People and Places ,Women's Health ,Population Groupings ,business ,Developmental Biology - Abstract
Copyright © Ordem dos Médicos 2020, The interesting paper from Yu and colleagues on the association of neonatal serum bilirubin and childhood hypertension recently published in Plos One, flagged up a plausible role of bilirubin as a mediator of hypertension in later life. This is a highly important topic since hypertension, a main cause of cardiometabolic associated morbidity and mortality, may affect 2% to 4% of children. Bilirubin is a toxic endproduct of heme catabolism in the body, commonly seen in newborns and causing jaundice. It is detoxified mainly in the liver by means of several steps involving circadian regulated enzymatic processes. A balanced autonomic output to the liver is crucial for maintenance of the circadian rhythmicity that ensures the normal function of liver metabolic enzymes and glucose level.
- Published
- 2020