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Physiological concentrations of thyroid hormones are necessary for skeletal development, the clinical trials indicating that euthyroid status is essential for a normal bone turnover, for a normal mineralization and for maintaining the optimal bone strength. The aim of the study was to observe the influence of the physiological values of FT4 on bone mineral density. We studied a total number of 650 patients, with and without thyroid pathology, divided into three groups and three age groups, in whom we dosed the thyroid hormones; bone mineral density was measured by the DEXA method. We analyzed the influence of FT4 on bone mineral density, we followed if there is a correlation between its physiological values and the T score independent of TSH. According to our study results and of the existing data in the literature, the idea that there is a direct relation between FT4 and the degree of bone demineralization can not be supported. [ABSTRACT FROM AUTHOR]

Thyroid hormones represented by triiodothyronine (T3), reverse triiodothyronine (T3) and tetraiodothyronine (thyroxine - T4) are important homeostatic regulators of bone metabolism. They are converted into active and inactive products by the 3 iodothyronin deiodinase D1, D2, D3, providing control tissue and cellular activity accomplished by the thyroid hormones and allow the body to adapt to various pathological changes. Thyroid hormone action on target cells is achieved through their receptors - TRα (α1, α2, α3) and TRβ (β1 and β2). Thyroid disorders affect bone remodelling cycle, either by variations of the circulating serum thyroid hormone levels, or because of the replacement or suppressive therapy with levothyroxine. [ABSTRACT FROM AUTHOR]

Thyroid hormones represented by triiodothyronine (T3), reverse triiodothyronine (T3) and tetraiodothyronine (thyroxine - T4) are important homeostatic regulators of bone metabolism. They are converted into active and inactive products by the 3 iodothyronin deiodinase D1, D2, D3, providing control tissue and cellular activity accomplished by the thyroid hormones and allow the body to adapt to various pathological changes. Thyroid hormone action on target cells is achieved through their receptors - TRα (α1, α2, α3) and TRβ (β1 and β2). Thyroid disorders affect bone remodelling cycle, either by variations of the circulating serum thyroid hormone levels, or because of the replacement or suppressive therapy with levothyroxine. [ABSTRACT FROM AUTHOR]

Objectives: the evaluation of the risk factors involved in iatrogenic biliary lesions produced in a tertiary biliary centre. Material and method: records of 21 consecutive patients with biliary tract injury produced between 2003 and 2008 in Surgical Clinic No. 3 of Cluj-Napoca were reviewed. Results: 57.1% of the lesions belonged to the type A class according to the Strasberg classification, and 42.9% to the types D-E. The annual incidence of the lesions was on the average of 0.22%. 76.2% of the lesions were secondary to emergency interventions. The risk factors were: the surgeon's experience, the lack of concentration by the experienced surgeons, modified local anatomy and the excessive use of the electrocautery. The complications were: 2 anastomotic fistulas, a stenosis of the main bile duct and one septic shock in a patient who died of multisystem organ failure. Conclusions: The best approach to a successful treatment remains the prevention of lesions. The multidisciplinary approach, from the identification of the lesion up to the surgical intervention, offers the best medium and long term results. [ABSTRACT FROM AUTHOR]

Objectives: the evaluation of the risk factors involved in iatrogenic biliary lesions produced in a tertiary biliary centre. Material and method: records of 21 consecutive patients with biliary tract injury produced between 2003 and 2008 in Surgical Clinic No. 3 of Cluj-Napoca were reviewed. Results: 57.1% of the lesions belonged to the type A class according to the Strasberg classification, and 42.9% to the types D-E. The annual incidence of the lesions was on the average of 0.22%. 76.2% of the lesions were secondary to emergency interventions. The risk factors were: the surgeon's experience, the lack of concentration by the experienced surgeons, modified local anatomy and the excessive use of the electrocautery. The complications were: 2 anastomotic fistulas, a stenosis of the main bile duct and one septic shock in a patient who died of multisystem organ failure. Conclusions: The best approach to a successful treatment remains the prevention of lesions. The multidisciplinary approach, from the identification of the lesion up to the surgical intervention, offers the best medium and long term results. [ABSTRACT FROM AUTHOR]

Copyright of Acta Medica Transilvanica is the property of Sciendo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Medica Transilvanica is the property of Sciendo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Thyroid disorders have a negative impact on bone metabolism; they influence bone remodelling cycle, either by changes in the circulating serum levels of the thyroid hormones, or as a result of the substitution or suppressive therapy with levothyroxine. Osteoporosis, considered a public health problem, is defined as a skeletal disease characterized by low bone strength due to the decreased bone mass and compromised bone quality. The study aims at analysing the serum variations of TSH, in the sense of increasing and decreasing its values, on bone mineral density; according to recent studies, it has been developed the idea that TSH is an important negative regulator of bone turn-over, its direct effect on bone mineral density, on formation and bone resorption indicators, being independent of thyroid hormone concentration. We analyzed a total of 650 women with and without thyroid pathology, aged between 50-70 years old, divided into three groups and three age groups. Low bone mineral density was associated both in hypothyroidism and in hyperthyroidism. [ABSTRACT FROM AUTHOR]

Thyroid disorders have a negative impact on bone metabolism; they influence bone remodelling cycle, either by changes in the circulating serum levels of the thyroid hormones, or as a result of the substitution or suppressive treatment with levothyroxine. Osteoporosis, considered a public health problem, is defined as a skeletal disease characterized by low bone strength due to the decreased bone mass and compromised bone quality. The study aims at analysing the serum variations of TSH, in the sense of increasing and decreasing its values, on bone mineral density; according to recent studies, it has been developed the idea that TSH is an important negative regulator of bone turn-over, its direct effect on bone mineral density, on formation and bone resorption indicators, being independent of thyroid hormone concentration. We analyzed a total of 650 women with and without thyroid pathology, aged between 50-70 years old, divided into three groups and three age groups. Low bone mineral density was associated both in hypothyroidism and in hyperthyroidism. [ABSTRACT FROM AUTHOR]

Physiological concentrations of thyroid hormones are necessary for skeletal development, the clinical trials indicating that euthyroid status is essential for a normal bone turnover, for a normal mineralization and for maintaining the optimal bone strength. The aim of the study was to observe the influence of the physiological values of FT4 on bone mineral density. We studied a total number of 650 patients, with and without thyroid pathology, divided into three groups and three age groups, in whom we dosed the thyroid hormones; bone mineral density was measured by the DEXA method. We analyzed the influence of FT4 on bone mineral density, we followed if there is a correlation between its physiological values and the T score independent of TSH. According to our study results and of the existing data in the literature, the idea that there is a direct relationship between FT4 and the degree of bone demineralization can not be supported. [ABSTRACT FROM AUTHOR]

In car battery technology production the occupational exposure to lead continues to be an important cause of morbidity. Monitoring the work environment and health status are efficient means within an integrated health and safety occupational strategy. The study aimed to assess the influence of occupational exposure to lead on the health of the workers in an environment characterized by inorganic lea, dust and pollution. There have been studied a number of 255workers. The subjects were structured into 3 groups: 165 subjects with continued lead exposure, 55 subjects with intermittent exposure and 35 subjects without exposure. We determined the blood pressure, pulse, electrocardiogram, ▵ ALA lead in value in urine. The results showed that mean lead value ▵ ALA were approximately 2 times higher iedn subjects exposed; the average blood pressure was within the normal range, and the percentage of subjects with elevated blood pressure and EKG changes didn't exceed the range of the general population; the neuroastenovegetativ, digestive and pseudoreumatismal syndromes are present in a small percentage; there is not evidence of a major health disorder in relation to occupational exposure to lead. [ABSTRACT FROM AUTHOR]

In the car battery technology production the occupational exposure to lead continues to be an important cause of morbidity. Monitoring the work environment and health status are efficient means within an integrated health and safety occupational strategy. [ABSTRACT FROM AUTHOR]