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Start Over Author "C. Zibera" Journal acta neurochirurgica
2 results on '"C. Zibera"'

1. Hormonal modulation of brain tumour growth: a cell culture study

Author

M. Scerrati, F. Iacopino, N. Gibelli, Giorgio Butti, Gigliola Sica, R. Assietti, R. Roselli, C. Zibera, Pietro Paoletti, Gian Franco Rossi, and G. Robustelli Della Cuna

Subjects
Male, medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, Dexamethasone, chemistry.chemical_compound, Tissue culture, Receptors, Glucocorticoid, Internal medicine, medicine, Meningeal Neoplasms, Tumor Cells, Cultured, Humans, Testosterone, Aged, Cell growth, Testosterone acetate, business.industry, Brain Neoplasms, Glioma, Middle Aged, Androgen, Steroid hormone, Endocrinology, chemistry, Cell culture, Hormone receptor, Receptors, Androgen, Surgery, Female, Neurology (clinical), Growth inhibition, business, Meningioma, Cell Division
Abstract

Tissue samples derived from two neuroepithelial tumours and five meningiomas were obtained at surgery from seven patients and cultured in order to study the effect of dexamethasone (DEX) and testosterone acetate (TA) on cell proliferation. Glucocorticoid and androgen receptors (GR, AR) were determined both on tissue samples (7 cases) and on five out of the seven cell cultures obtained by tumours. GR and AR were present respectively in 5 and in 4 out of the tumour specimens assayed and in 4/5 and 2/3 of the tested cell cultures. DEX activity on cell growth was tested on six cell cultures. Four of them showed a significant growth inhibition at the highest drug concentration. On the contrary, a significant growth stimulation was observed in four out of the five cultures, where GR were present, using low hormone concentrations. Treatment with pharmacological doses of TA caused a significant cytotoxicity in all the tested cultures. Low TA concentrations inhibited cell growth in one out of the two cell cultures which contained AR, but were ineffective in cultures lacking AR. Our preliminary results suggest a possible role in growth regulation by DEX and TA in intracranial tumours, on the basis of the presence of specific hormone receptors.

Published
1989

2. Hormonal modulation of brain tumour growth: a cell culture study.

Author

Gibelli N, Zibera C, Butti G, Assietti R, Sica G, Scerrati M, Iacopino F, Roselli R, Paoletti P, and Robustelli della Cuna G

Subjects
Aged, Cell Division drug effects, Female, Glioma, Humans, Male, Meningioma, Middle Aged, Tumor Cells, Cultured cytology, Tumor Cells, Cultured drug effects, Brain Neoplasms, Dexamethasone pharmacology, Meningeal Neoplasms, Receptors, Androgen drug effects, Receptors, Glucocorticoid drug effects, Testosterone pharmacology, Tumor Cells, Cultured metabolism
Abstract

Tissue samples derived from two neuroepithelial tumours and five meningiomas were obtained at surgery from seven patients and cultured in order to study the effect of dexamethasone (DEX) and testosterone acetate (TA) on cell proliferation. Glucocorticoid and androgen receptors (GR, AR) were determined both on tissue samples (7 cases) and on five out of the seven cell cultures obtained by tumours. GR and AR were present respectively in 5 and in 4 out of the tumour specimens assayed and in 4/5 and 2/3 of the tested cell cultures. DEX activity on cell growth was tested on six cell cultures. Four of them showed a significant growth inhibition at the highest drug concentration. On the contrary, a significant growth stimulation was observed in four out of the five cultures, where GR were present, using low hormone concentrations. Treatment with pharmacological doses of TA caused a significant cytotoxicity in all the tested cultures. Low TA concentrations inhibited cell growth in one out of the two cell cultures which contained AR, but were ineffective in cultures lacking AR. Our preliminary results suggest a possible role in growth regulation by DEX and TA in intracranial tumours, on the basis of the presence of specific hormone receptors.

Published
1989
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