Search

Three cases of acquired demyelinating multifocal neuropathy with persistent conduction blocks are reported. In one of them protyreline tartrate (TRH-T) had an evident deblocking effect; similar but milder effects were seen in the other two cases. The course and consistency of this effect is analyzed on the grounds of clinical and electromyographic findings. The nature of the THR-T responsive conduction block is analysed as a mild variant of CIDP with regard to its occurrence in a late and chronic phase without signs of active immune processes.

Electromyography and nerve conduction velocities were examined in 12 consecutive patients before and after 3 months treatment with carbamazepine. All parameters measured remained unchanged during treatment. Differences between the influence of carbamazepine and phenytoin on the peripheral nervous system are briefly discussed.