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Your search keyword '"Boddaert, Nathalie"' showing total 15 results
Start Over Author "Boddaert, Nathalie" Journal acta neuropathologica communications
15 results on '"Boddaert, Nathalie"'

2. CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas

Author

Tauziède-Espariat, Arnault, Nicaise, Yvan, Sievers, Philipp, Sahm, Felix, von Deimling, Andreas, Guillemot, Delphine, Pierron, Gaëlle, Duchesne, Mathilde, Edjlali, Myriam, Dangouloff-Ros, Volodia, Boddaert, Nathalie, Roux, Alexandre, Dezamis, Edouard, Hasty, Lauren, Lhermitte, Benoît, Hirsch, Edouard, Hirsch, Maria Paola Valenti, Ardellier, François-Daniel, Karnoub, Mélodie-Anne, Csanyi, Marie, Maurage, Claude-Alain, Mokhtari, Karima, Bielle, Franck, Rigau, Valérie, Roujeau, Thomas, Abad, Marine, Klein, Sébastien, Bernier, Michèle, Horodyckid, Catherine, Adam, Clovis, Brandal, Petter, Niehusmann, Pitt, Vannod-Michel, Quentin, Provost, Corentin, de Champfleur, Nicolas Menjot, Nichelli, Lucia, Métais, Alice, Mariet, Cassandra, Chrétien, Fabrice, Blauwblomme, Thomas, Beccaria, Kévin, Pallud, Johan, Puget, Stéphanie, Uro-Coste, Emmanuelle, and Varlet, Pascale

Published
2024
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3. CNS erythroblastic sarcoma: a potential emerging pediatric tumor type characterized by NFIA::RUNX1T1/3 fusions

Author

Tauziède-Espariat, Arnault, Lew-Derivry, Lucille, Abbou, Samuel, Métais, Alice, Pierron, Gaëlle, Reynaud, Stéphanie, Masliah-Planchon, Julien, Mariet, Cassandra, Hasty, Lauren, Dangouloff-Ros, Volodia, Boddaert, Nathalie, Csanyi, Marie, Aline-Fardin, Aude, Lamaison, Claire, Chrétien, Fabrice, Beccaria, Kévin, Puget, Stéphanie, and Varlet, Pascale

Published
2024
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7. The dural angioleiomyoma harbors frequent GJA4 mutation and a distinct DNA methylation profile

Author

Tauziède-Espariat, Arnault, Pierre, Thibaut, Wassef, Michel, Castel, David, Riant, Florence, Grill, Jacques, Roux, Alexandre, Pallud, Johan, Dezamis, Edouard, Bresson, Damien, Benichi, Sandro, Blauwblomme, Thomas, Benzohra, Djallel, Gauchotte, Guillaume, Pouget, Celso, Colnat-Coulbois, Sophie, Mokhtari, Karima, Balleyguier, Corinne, Larousserie, Frédérique, Dangouloff-Ros, Volodia, Boddaert, Nathalie, Debily, Marie-Anne, Hasty, Lauren, Polivka, Marc, Adle-Biassette, Homa, Métais, Alice, Lechapt, Emmanuèle, Chrétien, Fabrice, Sahm, Felix, Sievers, Philipp, and Varlet, Pascale

Published
2022
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9. Disseminated diffuse midline gliomas, H3K27-altered mimicking diffuse leptomeningeal glioneuronal tumors: a diagnostical challenge!

Author

Tauziède-Espariat, Arnault, Siegfried, Aurore, Uro-Coste, Emmanuelle, Nicaise, Yvan, Castel, David, Sevely, Annick, Gambart, Marion, Boetto, Sergio, Hasty, Lauren, Métais, Alice, Chrétien, Fabrice, Benzakoun, Joseph, Puget, Stéphanie, Grill, Jacques, Dangouloff-Ros, Volodia, Boddaert, Nathalie, Ebrahimi, Azadeh, and Varlet, Pascale

Published
2022
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10. The EP300:BCOR fusion extends the genetic alteration spectrum defining the new tumoral entity of “CNS tumors with BCOR internal tandem duplication”

Author

Tauziède-Espariat, Arnault, Pierron, Gaëlle, Siegfried, Aurore, Guillemot, Delphine, Uro-Coste, Emmanuelle, Nicaise, Yvan, Castel, David, Catalaa, Isabelle, Larrieu-Ciron, Delphine, Chaynes, Patrick, de Barros, Amaury, Nicolau, Julien, Gareton, Albane, Lechapt, Emmanuèle, Chrétien, Fabrice, Bourdeaut, Franck, Doz, François, Bouchoucha, Yassine, Grill, Jacques, Beccaria, Kévin, Boddaert, Nathalie, Saffroy, Raphaël, Pagès, Mélanie, and Varlet, Pascale

Published
2020
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11. A novel LARGE1-AFF2 fusion expanding the molecular alterations associated with the methylation class of neuroepithelial tumors with PATZ1 fusions

Author

Tauziède-Espariat, Arnault, Chotard, Guillaume, Le Loarer, François, Baud, Jessica, Azmani, Rihab, Dangouloff-Ros, Volodia, Boddaert, Nathalie, Icher-De-Bouyn, Céline, Gimbert, Edouard, Hasty, Lauren, Métais, Alice, Chrétien, Fabrice, Varlet, Pascale, GHU Paris Psychiatrie et Neurosciences, Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Service de pathologie [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Actions for OnCogenesis understanding and Target Identification in ONcology (ACTION), Institut Bergonié [Bordeaux], UNICANCER-UNICANCER-Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Biopathologie (Institut Bergonié - CRLCC Bordeaux), UNICANCER-UNICANCER, Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Département d'oncologie pédiatrique [CHU Bordeaux], Hôpital des Enfants - Groupe hospitalier Pellegrin - CHU de Bordeaux, CHU Bordeaux [Bordeaux], the RENOCLIP-LOC, and Martinez Rico, Clara

Subjects
Oncogene Proteins, Fusion, Brain Neoplasms, PATZ1, Kruppel-Like Transcription Factors, Nuclear Proteins, [SDV.CAN]Life Sciences [q-bio]/Cancer, Case Report, AFF2, N-Acetylglucosaminyltransferases, Neoplasms, Neuroepithelial, Neuroepithelial tumor, Repressor Proteins, [SDV.CAN] Life Sciences [q-bio]/Cancer, Child, Preschool, Humans, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Female, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], LARGE1
Abstract

A novel DNA methylation class of tumor within the central nervous system, the "neuroepithelial tumor (NET), PATZ1 fusion-positive” has recently been identified in the literature, characterized by EWSR1- and MN1-PATZ1 fusions. The cellular origin of this tumor type remains unknown, wavering between glioneuronal or mesenchymal (as round cell sarcomas with EWSR1-PATZ1 of the soft tissue). Because of the low number of reported cases, this tumor type will not be added to the 2021 World Health Organization Classification of Tumors of the Central Nervous System (CNS). Herein, we report one case of a CNS tumor classified by DNA methylation analysis as NET-PATZ1 but harboring a novel LARGE1-AFF2 fusion which has until now never been described in soft tissue or the CNS. We compare its clinical, histopathological, immunophenotypical, and genetic features with those previously described in NET-PATZ1. Interestingly, the current case presented histopathological (astroblastoma-like features, glioneuronal phenotype), clinical (with a favorable course), genetic (1p loss), and epigenetic (DNA-methylation profiling) similarities to previously reported cases of NET-PATZ1. Our results added data suggesting that different histomolecular tumor subtypes seem to be included within the methylation class “NET, PATZ1 fusion-positive”, including non PATZ1 fusions, and that further cases are needed to better characterize them. Supplementary Information The online version contains supplementary material available at 10.1186/s40478-022-01317-8.

Published
2021
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12. Papillary glioneuronal tumors: histological and molecular characteristics and diagnostic value of SLC44A1-PRKCA fusion

Author

Pages, Melanie, primary, Lacroix, Ludovic, additional, Tauziede-Espariat, Arnault, additional, Castel, David, additional, Daudigeos-Dubus, Estelle, additional, Ridola, Vita, additional, Gilles, Sophie, additional, Fina, Frederic, additional, Andreiuolo, Felipe, additional, Polivka, Marc, additional, Lechapt-Zalcman, Emmanuele, additional, Puget, Stephanie, additional, Boddaert, Nathalie, additional, Liu, Xiao-qiong, additional, Bridge, Julia A., additional, Grill, Jacques, additional, Chretien, Fabrice, additional, and Varlet, Pascale, additional

Published
2015
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13. CNS tumors with YWHAE:NUTM2 and KDM2B-fusions present molecular similarities to extra-CNS tumors having BCOR internal tandem duplication or alternative fusions.

Author

Tauziède-Espariat A, Pierron G, Guillemot D, Bochaton D, Watson S, Masliah-Planchon J, Vasiljevic A, Meurgey A, Chotard G, Hasty L, Wahler E, Lechapt E, Chrétien F, Grill J, Bourdeaut F, Bouchoucha Y, Puget S, Icher-de-Bouyn C, Jecko V, Cardoen L, Dangouloff-Ros V, Boddaert N, and Varlet P

Subjects
Child, Female, Humans, Infant, Male, Oncogene Proteins, Fusion genetics, Proto-Oncogene Proteins genetics, Repressor Proteins genetics, 14-3-3 Proteins genetics, Brain Neoplasms genetics, Brain Neoplasms pathology, F-Box Proteins genetics, Jumonji Domain-Containing Histone Demethylases genetics, Neoplasm Proteins genetics
Published
2021
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14. Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions.

Author

Tauziède-Espariat A, Siegfried A, Nicaise Y, Kergrohen T, Sievers P, Vasiljevic A, Roux A, Dezamis E, Benevello C, Machet MC, Michalak S, Puiseux C, Llamas-Gutierrez F, Leblond P, Bourdeaut F, Grill J, Dufour C, Guerrini-Rousseau L, Abbou S, Dangouloff-Ros V, Boddaert N, Saffroy R, Hasty L, Wahler E, Pagès M, Andreiuolo F, Lechapt E, Chrétien F, Blauwblomme T, Beccaria K, Pallud J, Puget S, Uro-Coste E, and Varlet P

Subjects
Adolescent, Adult, Child, Child, Preschool, DNA Methylation genetics, Ependymoma classification, Ependymoma metabolism, Ependymoma pathology, Female, Gene Fusion genetics, Genotype, Glial Fibrillary Acidic Protein metabolism, Humans, Infant, Male, NF-kappa B metabolism, Neural Cell Adhesion Molecule L1 metabolism, Nuclear Receptor Coactivator 1 genetics, Nuclear Receptor Coactivator 2 genetics, Phenotype, Supratentorial Neoplasms classification, Supratentorial Neoplasms metabolism, Supratentorial Neoplasms pathology, Trans-Activators genetics, Transcription Factor RelA genetics, Tumor Suppressor Proteins genetics, Young Adult, Ependymoma genetics, Proteins genetics, Supratentorial Neoplasms genetics
Abstract

The cIMPACT-NOW Update 7 has replaced the WHO nosology of "ependymoma, RELA fusion positive" by "Supratentorial-ependymoma, C11orf95-fusion positive". This modification reinforces the idea that supratentorial-ependymomas exhibiting fusion that implicates the C11orf95 (now called ZFTA) gene with or without the RELA gene, represent the same histomolecular entity. A hot off the press molecular study has identified distinct clusters of the DNA methylation class of ZFTA fusion-positive tumors. Interestingly, clusters 2 and 4 comprised tumors of different morphologies, with various ZFTA fusions without involvement of RELA. In this paper, we present a detailed series of thirteen cases of non-RELA ZFTA-fused supratentorial tumors with extensive clinical, radiological, histopathological, immunohistochemical, genetic and epigenetic (DNA methylation profiling) characterization. Contrary to the age of onset and MRI aspects similar to RELA fusion-positive EPN, we noted significant histopathological heterogeneity (pleomorphic xanthoastrocytoma-like, astroblastoma-like, ependymoma-like, and even sarcoma-like patterns) in this cohort. Immunophenotypically, these NFκB immunonegative tumors expressed GFAP variably, but EMA constantly and L1CAM frequently. Different gene partners were fused with ZFTA: NCOA1/2, MAML2 and for the first time MN1. These tumors had epigenetic homologies within the DNA methylation class of ependymomas-RELA and were classified as satellite clusters 2 and 4. Cluster 2 (n = 9) corresponded to tumors with classic ependymal histological features (n = 4) but also had astroblastic features (n = 5). Various types of ZFTA fusions were associated with cluster 2, but as in the original report, ZFTA:MAML2 fusion was frequent. Cluster 4 was enriched with sarcoma-like tumors. Moreover, we reported a novel anatomy of three ZFTA:NCOA1/2 fusions with only 1 ZFTA zinc finger domain in the putative fusion protein, whereas all previously reported non-RELA ZFTA fusions have 4 ZFTA zinc fingers. All three cases presented a sarcoma-like morphology. This genotype/phenotype association requires further studies for confirmation. Our series is the first to extensively characterize this new subset of supratentorial ZFTA-fused ependymomas and highlights the usefulness of ZFTA FISH analysis to confirm the existence of a rearrangement without RELA abnormality., (© 2021. The Author(s).)

Published
2021
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15. Pediatric methylation class HGNET-MN1: unresolved issues with terminology and grading.

Author

Tauziède-Espariat A, Pagès M, Roux A, Siegfried A, Uro-Coste E, Nicaise Y, Sevely A, Gambart M, Boetto S, Dupuy M, Richard P, Perbet R, Vinchon M, Caron S, Andreiuolo F, Gareton A, Lechapt E, Chrétien F, Puget S, Grill J, Boddaert N, and Varlet P

Subjects
Follow-Up Studies, Humans, Neoplasm Grading trends, Brain Neoplasms diagnosis, Brain Neoplasms genetics, Neoplasms, Neuroepithelial diagnosis, Neoplasms, Neuroepithelial genetics, Trans-Activators genetics, Tumor Suppressor Proteins genetics
Published
2019
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