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The article discusses the results of studies on the relationship between duration of untreated psychosis (DUP) and outcome. Imaging data indicate that if there is an active process of neuroprogression underlying active and progressive structural change in key brain areas such as the hippocampus, then the longer the DUP, the greater the time available for the potentially neurotoxic process to unfold.

The article focuses on the development of psychoeducation interventions to explain illness and treatment to patients with first-episode psychosis (FEP). These interventions are conducted in group, individual, or multifamily group formats to discuss the illness from a multidimensional viewpoint. Psychoeducational program used in a hospital unit specializing in the acute treatment of FEP patients comprises of four modules, including psychotic symptoms, cannabis and psychosis, psychosis and medication, and psychosis and recovery.