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Your search keyword '"Koefoed, Pernille"' showing total 3 results
Start Over Author "Koefoed, Pernille" Journal acta neuropsychiatrica
3 results on '"Koefoed, Pernille"'

1. Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression

Author

Koefoed, Pernille, Woldbye, David P.D., Hansen, Thomas v. O., Eplov, Lene F., Christiansen, Sren H., Mors, Ole, Kessing, Lars V., Werge, Thomas, Kaipio, Katja, Pesonen, Ullamari, Fahmy, Thomas, Mellerup, Erling, Jakobsen, Klaus D., Hansen, Elsebeth S., Knudsen, Gitte M., Bukh, Jens D., Bock, Camilla, Lindberg, Camilla, Kristensen, Ann S., Dam, Henrik, Nordentoft, Merete, Als, Thomas D., Wang, August G., Gether, Ulrik, Rehfeld, Jens F., and Bolwig, Tom G.

Published
2012
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3. No effect of escitalopram versus placebo on brain-derived neurotrophic factor in healthy individuals: a randomised trial.

Author

Knorr, Ulla, Koefoed, Pernille, Soendergaard, Mia H. Greisen, Vinberg, Maj, Gether, Ulrik, Gluud, Christian, Wetterslev, Jørn, Winkel, Per, and Kessing, Lars V.

Subjects
*ESCITALOPRAM, *MENTAL depression, *THERAPEUTICS, *NEUROTROPHINS, *ANTIDEPRESSANTS, *PSYCHIATRIC drugs
Abstract

ObjectiveBrain-derived neurotrophic factor (BDNF) seems to play an important role in the course of depression including the response to antidepressants in patients with depression. We aimed to study the effect of an antidepressant intervention on peripheral BDNF in healthy individuals with a family history of depression.MethodsWe measured changes in BDNF messenger RNA (mRNA) expression and whole-blood BDNF levels in 80 healthy first-degree relatives of patients with depression randomly allocated to receive daily tablets of escitalopram 10 mg versus placebo for 4 weeks.ResultsWe found no statistically significant difference between the escitalopram and the placebo group in the change in BDNF mRNA expression and whole-blood BDNF levels. Post hoc analyses showed a statistically significant negative correlation between plasma escitalopram concentration and change in whole-blood BDNF levels in the escitalopram-treated group.ConclusionThe results of this randomised trial suggest that escitalopram 10 mg has no effect on peripheral BDNF levels in healthy individuals. [ABSTRACT FROM PUBLISHER]

Published
2016
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