Search

Your search keyword '"Velakoulis, Dennis"' showing total 8 results
Start Over Author "Velakoulis, Dennis" Journal acta neuropsychiatrica
8 results on '"Velakoulis, Dennis"'

3. Cerebrospinal fluid neurofilament light predicts longitudinal diagnostic change in patients with psychiatric and neurodegenerative disorders

Author

Kang, Matthew J. Y., primary, Eratne, Dhamidhu, additional, Dobson, Hannah, additional, Malpas, Charles B., additional, Keem, Michael, additional, Lewis, Courtney, additional, Grewal, Jasleen, additional, Tsoukra, Vivian, additional, Dang, Christa, additional, Mocellin, Ramon, additional, Kalincik, Tomas, additional, Santillo, Alexander F., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Stehmann, Christiane, additional, Varghese, Shiji, additional, Li, Qiao-Xin, additional, Masters, Colin L., additional, Collins, Steven, additional, Berkovic, Samuel F., additional, Evans, Andrew, additional, Kelso, Wendy, additional, Farrand, Sarah, additional, Loi, Samantha M., additional, Walterfang, Mark, additional, and Velakoulis, Dennis, additional

Published
2023
Full Text
View/download PDF

8. Cerebrospinal fluid neurofilament light predicts longitudinal diagnostic change in patients with psychiatric and neurodegenerative disorders.

Author

Kang MJY, Eratne D, Dobson H, Malpas CB, Keem M, Lewis C, Grewal J, Tsoukra V, Dang C, Mocellin R, Kalincik T, Santillo AF, Zetterberg H, Blennow K, Stehmann C, Varghese S, Li QX, Masters CL, Collins S, Berkovic SF, Evans A, Kelso W, Farrand S, Loi SM, Walterfang M, and Velakoulis D

Subjects
Humans, Neurofilament Proteins cerebrospinal fluid, Intermediate Filaments, Biomarkers cerebrospinal fluid, Alzheimer Disease diagnosis, Neurodegenerative Diseases diagnosis, Neurodegenerative Diseases cerebrospinal fluid, Cognitive Dysfunction diagnosis
Abstract

Objective: People with neuropsychiatric symptoms often experience delay in accurate diagnosis. Although cerebrospinal fluid neurofilament light (CSF NfL) shows promise in distinguishing neurodegenerative disorders (ND) from psychiatric disorders (PSY), its accuracy in a diagnostically challenging cohort longitudinally is unknown., Methods: We collected longitudinal diagnostic information (mean = 36 months) from patients assessed at a neuropsychiatry service, categorising diagnoses as ND/mild cognitive impairment/other neurological disorders (ND/MCI/other) and PSY. We pre-specified NfL > 582 pg/mL as indicative of ND/MCI/other., Results: Diagnostic category changed from initial to final diagnosis for 23% (49/212) of patients. NfL predicted the final diagnostic category for 92% (22/24) of these and predicted final diagnostic category overall (ND/MCI/other vs. PSY) in 88% (187/212), compared to 77% (163/212) with clinical assessment alone., Conclusions: CSF NfL improved diagnostic accuracy, with potential to have led to earlier, accurate diagnosis in a real-world setting using a pre-specified cut-off, adding weight to translation of NfL into clinical practice.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results