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Your search keyword '"W. Heemsbergen"' showing total 2 results
Start Over Author "W. Heemsbergen" Journal acta oncologica
2 results on '"W. Heemsbergen"'

1. Long-term outcomes following stereotactic body radiotherapy boost for oropharyngeal squamous cell carcinoma

Author

Gerda M. Verduijn, Joost J. Nuyttens, Senada Koljenović, Hetty Mast, Aniel Sewnaik, W. Heemsbergen, Steven F. Petit, Sarah Baker, Radiotherapy, Otorhinolaryngology and Head and Neck Surgery, Oral and Maxillofacial Surgery, and Pathology

Subjects
Adult, Male, medicine.medical_specialty, Radiosurgery, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Long term outcomes, Carcinoma, medicine, Humans, Radiology, Nuclear Medicine and imaging, Oropharyngeal squamous cell carcinoma, Survival rate, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Dose fractionation, Retrospective cohort study, Hematology, General Medicine, Middle Aged, Prognosis, medicine.disease, Survival Rate, First line treatment, Oropharyngeal Neoplasms, Oncology, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Female, Dose Fractionation, Radiation, Radiology, business, Stereotactic body radiotherapy, Follow-Up Studies
Abstract

Background/purpose: To determine the efficacy and toxicity profile of a stereotactic body radiotherapy (SBRT) boost as a first line treatment in patients with oropharyngeal squamous cell carcinoma ...

Published
2019
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2. Prediction of early mortality following stereotactic body radiotherapy for peripheral early-stage lung cancer

Author

Joost J. Nuyttens, Aman Sharma, W. Heemsbergen, Robert Peric, Sarah Baker, Radiotherapy, and Pulmonary Medicine

Subjects
Adult, Male, Oncology, medicine.medical_specialty, Lung Neoplasms, Time Factors, Survivorship, Radiosurgery, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Text mining, SDG 3 - Good Health and Well-being, Carcinoma, Non-Small-Cell Lung, Internal medicine, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Stage (cooking), Lung cancer, Aged, Neoplasm Staging, Retrospective Studies, Aged, 80 and over, business.industry, Hematology, General Medicine, Middle Aged, Prognosis, medicine.disease, Survival Analysis, respiratory tract diseases, Peripheral, 030220 oncology & carcinogenesis, Female, Non small cell, business, Stereotactic body radiotherapy
Abstract

To investigate prognostic factors for death within 6 months of stereotactic body radiotherapy (SBRT) for patients with peripheral early-stage non-small cell lung cancer (NSCLC).This analysis included 586 NSCLC patients with peripheral tumors treated with SBRT. Potential patient and tumor prognostic factors, including the Charlson Comorbidity Index (CCI) and Cumulative Illness Rating Scale (CIRS), were analyzed by logistic regression analysis for association with early mortality (death6 months after SBRT). Additionally, CCI and CIRS were compared with respect to their predictive ability for early mortality by comparing multivariate models with each comorbidity index, and assessing their respective discriminatory abilities (C-index).A total of 36 patients (6.1%) died within 6 months of the start of SBRT. With a median follow-up of 25 months, 3-year overall survival was 54%. CIRS and tumor diameter were significant predictors of early mortality on multivariate analysis (p = .001). Patients with a CIRS score of 8 or higher and a tumor diameter over 3 cm had a 6-month survival of 70% versus 97% for those lacking these two features (p .001). CCI was not predictive for early mortality on univariate nor multivariate analysis; the model containing CCI had a C-index of 0.65 versus 0.70 for the model containing CIRS.CIRS and tumor diameter predict for early-mortality in peripheral early-stage NSCLC treated with SBRT. CIRS may be a more useful comorbidity index than CCI in this population when assessing short-term life expectancy.

Published
2019

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