1. The accuracy of target delineation in laryngeal and hypopharyngeal cancer.
- Author
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Caldas-Magalhaes J, Kooij N, Ligtenberg H, Jager EA, Schakel T, Kasperts N, Pameijer FA, Terhaard CH, Janssen LM, van Diest PJ, Philippens ME, and Raaijmakers CP
- Subjects
- Aged, Carcinoma, Squamous Cell pathology, Female, Humans, Hypopharyngeal Neoplasms pathology, Imaging, Three-Dimensional, Laryngeal Neoplasms pathology, Male, Middle Aged, Tomography, X-Ray Computed, Tumor Burden, Carcinoma, Squamous Cell diagnostic imaging, Hypopharyngeal Neoplasms diagnostic imaging, Laryngeal Neoplasms diagnostic imaging, Radiotherapy Planning, Computer-Assisted methods
- Abstract
Background and Purpose: To determine the spatial correspondence between the gross tumor volume (GTV) delineated on computer tomography (CT) and the actual tumor on histopathology., Material and Methods: Sixteen patients with T3 or T4 laryngeal or hypopharyngeal cancer underwent a CT scan before total laryngectomy. The GTV was delineated on CT by three independent observers and by consensus between the three observers. After surgery, whole-mount hematoxylin-eosin stained (H&E) sections were obtained. One pathologist delineated the tumor in the H&E sections (tumorH&E). The reconstructed specimen was registered to the CT scan in order to compare the GTV to the tumorH&E in three dimensions. The overlap between the GTV and the tumorH&E was calculated and the distance between the volumes was determined., Results: Tumor tissue was delineated in 203 of 516 H&E sections. For 14 patients a detailed analysis could be performed. The GTV volume was on average 1.7 times larger than the volume of the tumorH&E. The mean coverage of the tumorH&E by the consensus GTV was 88%. tumorH&E tissue was found at 1.6 mm to 12.9 mm distance outside the GTV depending on observer and patient., Conclusions: GTVs delineated on CT for laryngeal and hypopharyngeal cancer were 1.7 times larger than the tumor. Complete coverage of the tumor by the GTV was, however, not obtained.
- Published
- 2015
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